3uo8

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{{STRUCTURE_3uo8| PDB=3uo8 | SCENE= }}
 
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===Crystal structure of the MALT1 paracaspase (P1 form)===
 
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{{ABSTRACT_PUBMED_22158899}}
 
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==Disease==
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==Crystal structure of the MALT1 paracaspase (P1 form)==
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[[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
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<StructureSection load='3uo8' size='340' side='right'caption='[[3uo8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3uo8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UO8 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref><ref>PMID:14695475</ref><ref>PMID:18264101</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CF0:FLUOROMETHANE'>CF0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uo8 OCA], [https://pdbe.org/3uo8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uo8 RCSB], [https://www.ebi.ac.uk/pdbsum/3uo8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uo8 ProSAT]</span></td></tr>
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[[3uo8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UO8 OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
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<ref group="xtra">PMID:022158899</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref> <ref>PMID:14695475</ref> <ref>PMID:18264101</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Jeffrey, P D.]]
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[[Category: Large Structures]]
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[[Category: Shi, Y.]]
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[[Category: Jeffrey PD]]
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[[Category: Yu, J W.]]
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[[Category: Shi Y]]
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[[Category: Caspase fold]]
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[[Category: Yu JW]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Immunoglobulin fold]]
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[[Category: Lymphoma]]
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[[Category: Nf-kb signalling]]
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[[Category: Paracaspase]]
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Current revision

Crystal structure of the MALT1 paracaspase (P1 form)

PDB ID 3uo8

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