2cnq

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[[Image:2cnq.gif|left|200px]]<br /><applet load="2cnq" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2cnq, resolution 1.00&Aring;" />
 
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'''ATOMIC RESOLUTION STRUCTURE OF SAICAR-SYNTHASE FROM SACCHAROMYCES CEREVISIAE COMPLEXED WITH ADP, AICAR, SUCCINATE'''<br />
 
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==About this Structure==
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==Atomic resolution structure of SAICAR-synthase from Saccharomyces cerevisiae complexed with ADP, AICAR, succinate==
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2CNQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=ACE:'>ACE</scene>, <scene name='pdbligand=SIN:'>SIN</scene>, <scene name='pdbligand=ADP:'>ADP</scene>, <scene name='pdbligand=AMZ:'>AMZ</scene> and <scene name='pdbligand=AMP:'>AMP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazolesuccinocarboxamide_synthase Phosphoribosylaminoimidazolesuccinocarboxamide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.6 6.3.2.6] Known structural/functional Site: <scene name='pdbsite=AC2:So4+Binding+Site+For+Chain+A'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CNQ OCA].
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<StructureSection load='2cnq' size='340' side='right'caption='[[2cnq]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
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[[Category: Phosphoribosylaminoimidazolesuccinocarboxamide synthase]]
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== Structural highlights ==
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[[Category: Saccharomyces cerevisiae]]
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<table><tr><td colspan='2'>[[2cnq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CNQ FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
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[[Category: Antonyuk, S V.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Barynin, V V.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cnq OCA], [https://pdbe.org/2cnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cnq RCSB], [https://www.ebi.ac.uk/pdbsum/2cnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cnq ProSAT]</span></td></tr>
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[[Category: Grebenko, A I.]]
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</table>
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[[Category: Lamzin, V S.]]
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== Function ==
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[[Category: Levdikov, V M.]]
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[https://www.uniprot.org/uniprot/PUR7_YEAST PUR7_YEAST]
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[[Category: Melik-Adamyan, W R.]]
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== Evolutionary Conservation ==
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[[Category: Popov, A N.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Urusova, D V.]]
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Check<jmol>
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[[Category: ACE]]
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<jmolCheckbox>
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[[Category: ADP]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cn/2cnq_consurf.spt"</scriptWhenChecked>
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[[Category: AMP]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: AMZ]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: MG]]
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</jmolCheckbox>
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[[Category: SIN]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cnq ConSurf].
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[[Category: SO4]]
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<div style="clear:both"></div>
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[[Category: acetylation]]
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[[Category: atp-binding protein]]
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[[Category: phosphoribosylaminoimidazolesuccinocarboxamide (saicar) syn ligase]]
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[[Category: purine biosynthesis]]
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[[Category: synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:50:35 2008''
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==See Also==
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*[[SAICAR synthetase|SAICAR synthetase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Antonyuk SV]]
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[[Category: Barynin VV]]
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[[Category: Grebenko AI]]
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[[Category: Lamzin VS]]
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[[Category: Levdikov VM]]
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[[Category: Melik-Adamyan WR]]
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[[Category: Popov AN]]
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[[Category: Urusova DV]]

Current revision

Atomic resolution structure of SAICAR-synthase from Saccharomyces cerevisiae complexed with ADP, AICAR, succinate

PDB ID 2cnq

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