1jsg

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{{STRUCTURE_1jsg| PDB=1jsg | SCENE= }}
 
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===CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCT INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA, REVEALS A NOVEL B-BARREL TOPOLOGY===
 
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{{ABSTRACT_PUBMED_9519406}}
 
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==Disease==
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==CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCT INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA, REVEALS A NOVEL B-BARREL TOPOLOGY==
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[[http://www.uniprot.org/uniprot/TCL1A_HUMAN TCL1A_HUMAN]] Note=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
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<StructureSection load='1jsg' size='340' side='right'caption='[[1jsg]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[1jsg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JSG FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/TCL1A_HUMAN TCL1A_HUMAN]] Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.<ref>PMID:10983986</ref><ref>PMID:10716693</ref><ref>PMID:11707444</ref><ref>PMID:11839817</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jsg OCA], [https://pdbe.org/1jsg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jsg RCSB], [https://www.ebi.ac.uk/pdbsum/1jsg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jsg ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1jsg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSG OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/TCL1A_HUMAN TCL1A_HUMAN] Note=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
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==Reference==
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== Function ==
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<ref group="xtra">PMID:009519406</ref><references group="xtra"/><references/>
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[https://www.uniprot.org/uniprot/TCL1A_HUMAN TCL1A_HUMAN] Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.<ref>PMID:10983986</ref> <ref>PMID:10716693</ref> <ref>PMID:11707444</ref> <ref>PMID:11839817</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/1jsg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jsg ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Guignard, L.]]
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[[Category: Large Structures]]
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[[Category: Hoh, F.]]
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[[Category: Guignard L]]
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[[Category: Lhoste, J M.]]
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[[Category: Hoh F]]
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[[Category: Padilla, A.]]
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[[Category: Lhoste J-M]]
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[[Category: Stern, R H.]]
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[[Category: Padilla A]]
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[[Category: Tilbeurgh, H Van.]]
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[[Category: Stern R-H]]
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[[Category: Yang, Y S.]]
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[[Category: Van Tilbeurgh H]]
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[[Category: Cl1 gene]]
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[[Category: Yang Y-S]]
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[[Category: Microsome]]
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[[Category: Oncoprotein]]
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[[Category: Proto-oncogene]]
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[[Category: T cell leukemia]]
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Current revision

CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCT INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA, REVEALS A NOVEL B-BARREL TOPOLOGY

PDB ID 1jsg

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