3eqm

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{{STRUCTURE_3eqm| PDB=3eqm | SCENE= }}
 
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===Crystal structure of human placental aromatase cytochrome P450 in complex with androstenedione===
 
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{{ABSTRACT_PUBMED_19129847}}
 
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==Disease==
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==Crystal structure of human placental aromatase cytochrome P450 in complex with androstenedione==
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[[http://www.uniprot.org/uniprot/CP19A_HUMAN CP19A_HUMAN]] Defects in CYP19A1 are a cause of aromatase excess syndrome (AEXS) [MIM:[http://omim.org/entry/139300 139300]]; also known as familial gynecomastia. AEXS is characterized by an estrogen excess due to an increased aromatase activity. Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:[http://omim.org/entry/613546 613546]]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.<ref>PMID:8265607</ref><ref>PMID:8530621</ref><ref>PMID:9211678</ref>
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<StructureSection load='3eqm' size='340' side='right'caption='[[3eqm]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3eqm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EQM FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/CP19A_HUMAN CP19A_HUMAN]] Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASD:4-ANDROSTENE-3-17-DIONE'>ASD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eqm OCA], [https://pdbe.org/3eqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eqm RCSB], [https://www.ebi.ac.uk/pdbsum/3eqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eqm ProSAT]</span></td></tr>
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[[3eqm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EQM OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CP19A_HUMAN CP19A_HUMAN] Defects in CYP19A1 are a cause of aromatase excess syndrome (AEXS) [MIM:[https://omim.org/entry/139300 139300]; also known as familial gynecomastia. AEXS is characterized by an estrogen excess due to an increased aromatase activity. Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:[https://omim.org/entry/613546 613546]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.<ref>PMID:8265607</ref> <ref>PMID:8530621</ref> <ref>PMID:9211678</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CP19A_HUMAN CP19A_HUMAN] Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eq/3eqm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eqm ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aromatase|Aromatase]]
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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*[[Cytochrome P450|Cytochrome P450]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019129847</ref><references group="xtra"/><references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Unspecific monooxygenase]]
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[[Category: Large Structures]]
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[[Category: Ghosh, D.]]
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[[Category: Ghosh D]]
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[[Category: Biosynthesis of steroid hormone]]
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[[Category: Cytochrome p450]]
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[[Category: Disease mutation]]
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[[Category: Estrogen]]
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[[Category: Heme]]
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[[Category: Human aromatase]]
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[[Category: Iron]]
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[[Category: Membrane protein]]
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[[Category: Metal-binding]]
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[[Category: Microsomal]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: Phosphoprotein]]
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Current revision

Crystal structure of human placental aromatase cytochrome P450 in complex with androstenedione

PDB ID 3eqm

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