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2f83
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| - | {{STRUCTURE_2f83| PDB=2f83 | SCENE= }}
| + | #REDIRECT [[6i58]] This PDB entry is obsolete and replaced by 6i58 |
| - | ===Crystal structure at 2.9 Angstroms resolution of human plasma coagulation factor XI zymogen===
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| - | {{ABSTRACT_PUBMED_16699514}}
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| - | ==Disease==
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| - | [[http://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:[http://omim.org/entry/612416 612416]]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.<ref>PMID:2813350</ref><ref>PMID:1547342</ref><ref>PMID:7888672</ref><ref>PMID:7669672</ref><ref>PMID:9401068</ref><ref>PMID:9787168</ref><ref>PMID:10027710</ref><ref>PMID:10606881</ref><ref>PMID:11895778</ref><ref>PMID:15026311</ref><ref>PMID:15180874</ref><ref>PMID:15953011</ref><ref>PMID:16607084</ref><ref>PMID:18005151</ref><ref>PMID:21668437</ref><ref>PMID:21457405</ref><ref>PMID:22016685</ref><ref>PMID:22322133</ref><ref>PMID:21999818</ref><ref>PMID:22159456</ref> | + | |
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| - | ==Function==
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| - | [[http://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
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| - | ==About this Structure==
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| - | [[2f83]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F83 OCA].
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| - | ==See Also==
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| - | *[[Factor XIa|Factor XIa]]
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| - | *[[RNA polymerase|RNA polymerase]]
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| - | ==Reference==
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| - | <ref group="xtra">PMID:016699514</ref><references group="xtra"/><references/>
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| - | [[Category: Coagulation factor XIa]]
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Emsley, J.]]
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| - | [[Category: McEwan, P A.]]
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| - | [[Category: Papagrigoriou, E.]]
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| - | [[Category: Walsh, P N.]]
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| - | [[Category: Apple domain]]
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| - | [[Category: Hydrolase]]
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| - | [[Category: Protease]]
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Current revision
- REDIRECT 6i58 This PDB entry is obsolete and replaced by 6i58
