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2cqy

From Proteopedia

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[[Image:2cqy.gif|left|200px]]<br /><applet load="2cqy" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2cqy" />
 
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'''Solution structure of B domain from human propionyl-CoA carboxylase alpha subunit'''<br />
 
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==Disease==
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==Solution structure of B domain from human propionyl-CoA carboxylase alpha subunit==
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Known disease associated with this structure: Propionicacidemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=232000 232000]]
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<StructureSection load='2cqy' size='340' side='right'caption='[[2cqy]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2cqy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CQY FirstGlance]. <br>
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2CQY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Propionyl-CoA_carboxylase Propionyl-CoA carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.4.1.3 6.4.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQY OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cqy OCA], [https://pdbe.org/2cqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cqy RCSB], [https://www.ebi.ac.uk/pdbsum/2cqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cqy ProSAT], [https://www.topsan.org/Proteins/RSGI/2cqy TOPSAN]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PCCA_HUMAN PCCA_HUMAN] Defects in PCCA are the cause of propionic acidemia type I (PA-1) [MIM:[https://omim.org/entry/606054 606054]. PA-1 is a life-threatening disease characterized by episodic vomiting, lethargy and ketosis, neutropenia, periodic thrombocytopenia, hypogammaglobulinemia, developmental retardation, and intolerance to protein.<ref>PMID:10101253</ref> <ref>PMID:12559849</ref> <ref>PMID:15059621</ref> <ref>PMID:10329019</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PCCA_HUMAN PCCA_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/2cqy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cqy ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Propionyl-CoA carboxylase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Hayashi F]]
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[[Category: Hayashi, F.]]
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[[Category: Suetake T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Yokoyama S]]
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[[Category: Suetake, T.]]
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[[Category: Yokoyama, S.]]
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[[Category: b domain]]
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[[Category: national project on protein structural and functional analyses]]
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[[Category: nppsfa]]
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[[Category: pcca]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:51:30 2008''
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Current revision

Solution structure of B domain from human propionyl-CoA carboxylase alpha subunit

PDB ID 2cqy

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