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2kn1
From Proteopedia
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| - | {{STRUCTURE_2kn1| PDB=2kn1 | SCENE= }} | ||
| - | ===Solution NMR Structure of BCMA=== | ||
| - | == | + | ==Solution NMR Structure of BCMA== |
| - | [[http://www.uniprot.org/uniprot/TNR17_HUMAN TNR17_HUMAN | + | <StructureSection load='2kn1' size='340' side='right'caption='[[2kn1]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2kn1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KN1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CY1:ACETAMIDOMETHYLCYSTEINE'>CY1</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kn1 OCA], [https://pdbe.org/2kn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kn1 RCSB], [https://www.ebi.ac.uk/pdbsum/2kn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kn1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TNR17_HUMAN TNR17_HUMAN] Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TNR17_HUMAN TNR17_HUMAN] Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.<ref>PMID:10903733</ref> <ref>PMID:10801128</ref> <ref>PMID:10973284</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | TWEAK (TNF homologue with weak apoptosis-inducing activity) and Fn14 (fibroblast growth factor-inducible protein 14) are members of the tumor necrosis factor (TNF) ligand and receptor super-families. Having observed that Xenopus Fn14 cross-reacts with human TWEAK, despite its relatively low sequence homology to human Fn14, we examined the conservation in tertiary fold and binding interfaces between the two species. Our results, combining NMR solution structure determination, binding assays, extensive site-directed mutagenesis and molecular modeling, reveal that, in addition to the known and previously characterized beta-hairpin motif, the helix-loop-helix motif makes an essential contribution to the receptor/ligand binding interface. We further discuss the insight provided by the structural analyses regarding how the cysteine-rich domains of the TNF receptor super-family may have evolved over time. DATABASE: Structural data are available in the Protein Data Bank/BioMagResBank databases under the accession codes 2KMZ, 2KN0 and 2KN1 and 17237, 17247 and 17252. STRUCTURED DIGITAL ABSTRACT: TWEAK binds to hFn14 by surface plasmon resonance (View interaction) xeFn14 binds to TWEAK by enzyme linked immunosorbent assay (View interaction) TWEAK binds to xeFn14 by surface plasmon resonance (View interaction) hFn14 binds to TWEAK by enzyme linked immunosorbent assay (View interaction). | ||
| - | + | Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions.,Pellegrini M, Willen L, Perroud M, Krushinskie D, Strauch K, Cuervo H, Day ES, Schneider P, Zheng TS FEBS J. 2013 Feb 25. doi: 10.1111/febs.12206. PMID:23438059<ref>PMID:23438059</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| + | <div class="pdbe-citations 2kn1" style="background-color:#fffaf0;"></div> | ||
| - | == | + | ==See Also== |
| - | <references | + | *[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]] |
| - | [[Category: Cuervo | + | == References == |
| - | [[Category: Day | + | <references/> |
| - | [[Category: Krushinskie | + | __TOC__ |
| - | [[Category: Pellegrini | + | </StructureSection> |
| - | [[Category: Perroud | + | [[Category: Homo sapiens]] |
| - | [[Category: Schneider | + | [[Category: Large Structures]] |
| - | [[Category: Strauch | + | [[Category: Cuervo H]] |
| - | [[Category: Sun | + | [[Category: Day ES]] |
| - | [[Category: Willen | + | [[Category: Krushinskie D]] |
| - | [[Category: Zheng | + | [[Category: Pellegrini M]] |
| - | + | [[Category: Perroud M]] | |
| - | + | [[Category: Schneider P]] | |
| - | + | [[Category: Strauch K]] | |
| - | + | [[Category: Sun Y]] | |
| - | + | [[Category: Willen L]] | |
| - | + | [[Category: Zheng TS]] | |
Current revision
Solution NMR Structure of BCMA
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Categories: Homo sapiens | Large Structures | Cuervo H | Day ES | Krushinskie D | Pellegrini M | Perroud M | Schneider P | Strauch K | Sun Y | Willen L | Zheng TS
