3at0

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{{STRUCTURE_3at0| PDB=3at0 | SCENE= }}
 
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===Structural and biochemical characterization of ClfB:ligand interactions===
 
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{{ABSTRACT_PUBMED_021543319}}
 
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==Disease==
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==Structural and biochemical characterization of ClfB:ligand interactions==
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[[http://www.uniprot.org/uniprot/FIBA_HUMAN FIBA_HUMAN]] Defects in FGA are a cause of congenital afibrinogenemia (CAFBN) [MIM:[http://omim.org/entry/202400 202400]]. This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias. Defects in FGA are a cause of amyloidosis type 8 (AMYL8) [MIM:[http://omim.org/entry/105200 105200]]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.<ref>PMID:8097946</ref>
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<StructureSection load='3at0' size='340' side='right'caption='[[3at0]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3at0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AT0 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/CLFB_STAAN CLFB_STAAN]] Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps (By similarity). [[http://www.uniprot.org/uniprot/FIBA_HUMAN FIBA_HUMAN]] Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3at0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3at0 OCA], [https://pdbe.org/3at0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3at0 RCSB], [https://www.ebi.ac.uk/pdbsum/3at0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3at0 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3at0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AT0 OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/CLFB_STAAN CLFB_STAAN] Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps (By similarity).
==See Also==
==See Also==
*[[Fibrinogen binding protein|Fibrinogen binding protein]]
*[[Fibrinogen binding protein|Fibrinogen binding protein]]
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__TOC__
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==Reference==
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</StructureSection>
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Staphylococcus aureus]]
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[[Category: Large Structures]]
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[[Category: Ganesh, V K.]]
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[[Category: Staphylococcus aureus subsp. aureus N315]]
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[[Category: Adhesin]]
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[[Category: Ganesh VK]]
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[[Category: Cell adhesion-blood clotting complex]]
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[[Category: Cytokeratin]]
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[[Category: Fibrinogen]]
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[[Category: Igg like]]
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Current revision

Structural and biochemical characterization of ClfB:ligand interactions

PDB ID 3at0

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