3ifq

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{{STRUCTURE_3ifq| PDB=3ifq | SCENE= }}
 
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===Interction of plakoglobin and beta-catenin with desmosomal cadherins===
 
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{{ABSTRACT_PUBMED_19759396}}
 
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==Disease==
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==Interction of plakoglobin and beta-catenin with desmosomal cadherins==
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[[http://www.uniprot.org/uniprot/PLAK_HUMAN PLAK_HUMAN]] Defects in JUP are the cause of Naxos disease (NXD) [MIM:[http://omim.org/entry/601214 601214]]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.<ref>PMID:10902626</ref> Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:[http://omim.org/entry/611528 611528]]; also called arrhythmogenic right ventricular cardiomyopathy 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.<ref>PMID:10902626</ref><ref>PMID:17924338</ref><ref>PMID:20031617</ref>
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<StructureSection load='3ifq' size='340' side='right'caption='[[3ifq]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3ifq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IFQ FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/PLAK_HUMAN PLAK_HUMAN]] Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). [[http://www.uniprot.org/uniprot/CADH1_MOUSE CADH1_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ifq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ifq OCA], [https://pdbe.org/3ifq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ifq RCSB], [https://www.ebi.ac.uk/pdbsum/3ifq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ifq ProSAT]</span></td></tr>
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[[3ifq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IFQ OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PLAK_HUMAN PLAK_HUMAN] Defects in JUP are the cause of Naxos disease (NXD) [MIM:[https://omim.org/entry/601214 601214]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.<ref>PMID:10902626</ref> Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:[https://omim.org/entry/611528 611528]; also called arrhythmogenic right ventricular cardiomyopathy 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.<ref>PMID:10902626</ref> <ref>PMID:17924338</ref> <ref>PMID:20031617</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PLAK_HUMAN PLAK_HUMAN] Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/3ifq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ifq ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cadherin|Cadherin]]
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*[[Cadherin 3D structures|Cadherin 3D structures]]
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*[[Catenin|Catenin]]
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*[[Catenin 3D structures|Catenin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019759396</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Choi, H J.]]
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[[Category: Choi H-J]]
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[[Category: Gross, J C.]]
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[[Category: Gross JC]]
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[[Category: Pokutta, S.]]
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[[Category: Pokutta S]]
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[[Category: Weis, W I.]]
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[[Category: Weis WI]]
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[[Category: Armadillo repeat]]
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[[Category: Cardiomyopathy]]
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[[Category: Cell adhesion]]
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[[Category: Cell junction]]
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[[Category: Cell membrane]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Cytoskeleton]]
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[[Category: Disease mutation]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Membrane]]
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[[Category: Palmoplantar keratoderma]]
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[[Category: Phosphoprotein]]
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[[Category: Transmembrane]]
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Current revision

Interction of plakoglobin and beta-catenin with desmosomal cadherins

PDB ID 3ifq

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