3up3

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{{STRUCTURE_3up3| PDB=3up3 | SCENE= }}
 
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===Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-cholestenoic acid===
 
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{{ABSTRACT_PUBMED_22170062}}
 
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==Disease==
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==Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-cholestenoic acid==
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[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
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<StructureSection load='3up3' size='340' side='right'caption='[[3up3]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3up3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UP3 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=XCA:(8ALPHA,10ALPHA,25S)-3-HYDROXYCHOLESTA-3,5-DIEN-26-OIC+ACID'>XCA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3up3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3up3 OCA], [https://pdbe.org/3up3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3up3 RCSB], [https://www.ebi.ac.uk/pdbsum/3up3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3up3 ProSAT]</span></td></tr>
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[[3up3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UP3 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/H0USY8_9BILA H0USY8_9BILA]
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<ref group="xtra">PMID:022170062</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Ancylostoma ceylanicum]]
[[Category: Ancylostoma ceylanicum]]
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[[Category: Gelmedin, V.]]
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[[Category: Homo sapiens]]
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[[Category: Hawdon, J.]]
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[[Category: Large Structures]]
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[[Category: Kliewer, S A.]]
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[[Category: Gelmedin V]]
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[[Category: Mangelsdorf, D J.]]
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[[Category: Hawdon J]]
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[[Category: Melcher, K.]]
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[[Category: Kliewer SA]]
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[[Category: Motola, D L.]]
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[[Category: Mangelsdorf DJ]]
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[[Category: Xu, H E.]]
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[[Category: Melcher K]]
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[[Category: Zhi, X.]]
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[[Category: Motola DL]]
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[[Category: Zhou, X E.]]
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[[Category: Xu HE]]
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[[Category: Ligand binding domain]]
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[[Category: Zhi X]]
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[[Category: Nematode]]
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[[Category: Zhou XE]]
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[[Category: Steroid binding protein-transcription complex]]
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Current revision

Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-cholestenoic acid

PDB ID 3up3

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