1nrl

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{{STRUCTURE_1nrl| PDB=1nrl | SCENE= }}
 
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===Crystal Structure of the human PXR-LBD in complex with an SRC-1 coactivator peptide and SR12813===
 
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{{ABSTRACT_PUBMED_12909012}}
 
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==Function==
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==Crystal Structure of the human PXR-LBD in complex with an SRC-1 coactivator peptide and SR12813==
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[[http://www.uniprot.org/uniprot/NR1I2_HUMAN NR1I2_HUMAN]] Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<ref>PMID:9727070</ref><ref>PMID:11668216</ref><ref>PMID:11297522</ref><ref>PMID:19297428</ref><ref>PMID:12578355</ref><ref>PMID:18768384</ref>
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<StructureSection load='1nrl' size='340' side='right'caption='[[1nrl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nrl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NRL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SRL:[2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC+ACID+DIETHLYL+ESTER'>SRL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nrl OCA], [https://pdbe.org/1nrl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nrl RCSB], [https://www.ebi.ac.uk/pdbsum/1nrl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nrl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR1I2_HUMAN NR1I2_HUMAN] Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<ref>PMID:9727070</ref> <ref>PMID:11668216</ref> <ref>PMID:11297522</ref> <ref>PMID:19297428</ref> <ref>PMID:12578355</ref> <ref>PMID:18768384</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nr/1nrl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nrl ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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[[1nrl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NRL OCA].
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*[[Pregnane X receptor 3D structures|Pregnane X receptor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012909012</ref><ref group="xtra">PMID:012740396</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Davis-Searles, P R.]]
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[[Category: Large Structures]]
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[[Category: Lambert, M H.]]
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[[Category: Davis-Searles PR]]
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[[Category: Redinbo, M R.]]
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[[Category: Lambert MH]]
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[[Category: Watkins, R E.]]
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[[Category: Redinbo MR]]
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[[Category: Coactivator]]
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[[Category: Watkins RE]]
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[[Category: Ligand binding domain]]
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[[Category: Nuclear receptor]]
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[[Category: Pxr]]
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[[Category: Src-1]]
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[[Category: Transcription]]
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[[Category: Xenobiotic]]
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Current revision

Crystal Structure of the human PXR-LBD in complex with an SRC-1 coactivator peptide and SR12813

PDB ID 1nrl

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