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3vfp

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{{STRUCTURE_3vfp| PDB=3vfp | SCENE= }}
 
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===crystal structure of HLA B*3508 LPEP158G, HLA mutant Gly158===
 
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{{ABSTRACT_PUBMED_22343629}}
 
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==Disease==
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==crystal structure of HLA B*3508 LPEP158G, HLA mutant Gly158==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:19284997</ref>
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<StructureSection load='3vfp' size='340' side='right'caption='[[3vfp]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3vfp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_herpesvirus_4_strain_B95-8 Human herpesvirus 4 strain B95-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VFP FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/C5MK56_HUMAN C5MK56_HUMAN]] Involved in the presentation of foreign antigens to the immune system (By similarity).[SAAS:SAAS003006_004_004364] [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vfp OCA], [https://pdbe.org/3vfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vfp RCSB], [https://www.ebi.ac.uk/pdbsum/3vfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vfp ProSAT]</span></td></tr>
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[[3vfp]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFP OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/C5MK56_HUMAN C5MK56_HUMAN] Involved in the presentation of foreign antigens to the immune system (By similarity).[SAAS:SAAS003006_004_004364]
==See Also==
==See Also==
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*[[Beta-2 microglobulin|Beta-2 microglobulin]]
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:022343629</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Gras, S.]]
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[[Category: Human herpesvirus 4 strain B95-8]]
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[[Category: Liu, Y C.]]
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[[Category: Large Structures]]
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[[Category: Rossjohn, J.]]
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[[Category: Gras S]]
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[[Category: Antigen-presenting molecule]]
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[[Category: Liu YC]]
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[[Category: Epstein barr virus]]
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[[Category: Rossjohn J]]
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[[Category: Hla b*3508]]
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[[Category: Immune system]]
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[[Category: T cell]]
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[[Category: Tcr]]
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Current revision

crystal structure of HLA B*3508 LPEP158G, HLA mutant Gly158

PDB ID 3vfp

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