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| - | {{STRUCTURE_3cxe| PDB=3cxe | SCENE= }}
| + | #REDIRECT [[4nkq]] This PDB entry is obsolete and replaced by 4nkq |
| - | ===Structure of the GM-CSF Receptor Complex===
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| - | {{ABSTRACT_PUBMED_18692472}}
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| - | ==Disease==
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| - | [[http://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN]] Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:[http://omim.org/entry/614370 614370]]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:21075760</ref> [[http://www.uniprot.org/uniprot/CSF2R_HUMAN CSF2R_HUMAN]] Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:[http://omim.org/entry/300770 300770]]. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:18955567</ref><ref>PMID:18955570</ref> | + | |
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| - | ==Function==
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| - | [[http://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN]] High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. [[http://www.uniprot.org/uniprot/CSF2R_HUMAN CSF2R_HUMAN]] Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. [[http://www.uniprot.org/uniprot/CSF2_HUMAN CSF2_HUMAN]] Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
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| - | ==About this Structure==
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| - | [[3cxe]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXE OCA].
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| - | ==Reference==
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| - | <ref group="xtra">PMID:018692472</ref><references group="xtra"/><references/>
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Hansen, G.]]
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| - | [[Category: Hercus, T R.]]
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| - | [[Category: Lopez, A F.]]
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| - | [[Category: McClure, B J.]]
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| - | [[Category: McKinstry, W J.]]
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| - | [[Category: Parker, M W.]]
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| - | [[Category: Stomski, F C.]]
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| - | [[Category: Woodcock, J M.]]
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| - | [[Category: Xu, Y.]]
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| - | [[Category: Cytokine]]
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| - | [[Category: Disease mutation]]
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| - | [[Category: Dodecamer]]
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| - | [[Category: Glycoprotein]]
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| - | [[Category: Gm-csf]]
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| - | [[Category: Growth factor]]
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| - | [[Category: Membrane]]
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| - | [[Category: Phosphoprotein]]
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| - | [[Category: Receptor complex]]
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| - | [[Category: Secreted]]
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| - | [[Category: Transmembrane]]
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