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3v31

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{{STRUCTURE_3v31| PDB=3v31 | SCENE= }}
 
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===Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human ANKRA2===
 
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{{ABSTRACT_PUBMED_22649097}}
 
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==Disease==
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==Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human ANKRA2==
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[[http://www.uniprot.org/uniprot/HDAC4_HUMAN HDAC4_HUMAN]] Defects in HDAC4 are the cause of brachydactyly-mental retardation syndrome (BDMR) [MIM:[http://omim.org/entry/600430 600430]]. A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, developmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism.<ref>PMID:20691407</ref>
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<StructureSection load='3v31' size='340' side='right'caption='[[3v31]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3v31]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V31 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V31 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/ANRA2_HUMAN ANRA2_HUMAN]] May facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery. [[http://www.uniprot.org/uniprot/HDAC4_HUMAN HDAC4_HUMAN]] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.<ref>PMID:10523670</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v31 OCA], [https://pdbe.org/3v31 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v31 RCSB], [https://www.ebi.ac.uk/pdbsum/3v31 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v31 ProSAT]</span></td></tr>
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[[3v31]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V31 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/ANRA2_HUMAN ANRA2_HUMAN] May facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery.
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<ref group="xtra">PMID:022649097</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Histone deacetylase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bian, C B.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bian CB]]
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[[Category: Bountra, C.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M.]]
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[[Category: Bountra C]]
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[[Category: Kania, J.]]
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[[Category: Edwards AM]]
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[[Category: Lam, R.]]
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[[Category: Kania J]]
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[[Category: Min, J.]]
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[[Category: Lam R]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Min J]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Xu, C.]]
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[[Category: Xu C]]
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[[Category: Ank repeat]]
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[[Category: Ankra2]]
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[[Category: Hdac4]]
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[[Category: Protein binding]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human ANKRA2

PDB ID 3v31

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