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2cz6

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[[Image:2cz6.gif|left|200px]]<br /><applet load="2cz6" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2cz6, resolution 1.50&Aring;" />
 
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'''Complex of Inactive Fe-type NHase with Cyclohexyl isocyanide'''<br />
 
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==About this Structure==
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==Complex of Inactive Fe-type NHase with Cyclohexyl isocyanide==
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2CZ6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rhodococcus_erythropolis Rhodococcus erythropolis] with <scene name='pdbligand=FE:'>FE</scene>, <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=NO:'>NO</scene> and <scene name='pdbligand=CYI:'>CYI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Nitrile_hydratase Nitrile hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.84 4.2.1.84] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZ6 OCA].
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<StructureSection load='2cz6' size='340' side='right'caption='[[2cz6]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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[[Category: Nitrile hydratase]]
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== Structural highlights ==
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[[Category: Protein complex]]
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<table><tr><td colspan='2'>[[2cz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_erythropolis Rhodococcus erythropolis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CZ6 FirstGlance]. <br>
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[[Category: Rhodococcus erythropolis]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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[[Category: Hashimoto, K.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=CYI:CYCLOHEXYL+ISOCYANIDE'>CYI</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene></td></tr>
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[[Category: Kamiya, N.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cz6 OCA], [https://pdbe.org/2cz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2cz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cz6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cz6 TOPSAN]</span></td></tr>
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[[Category: Kawano, Y.]]
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</table>
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[[Category: Nojiri, M.]]
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== Function ==
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[https://www.uniprot.org/uniprot/NHAA_RHOER NHAA_RHOER] NHase catalyzes the hydration of various nitrile compounds to the corresponding amides. Industrial production of acrylamide is now being developed using some of the enzymes of this class.
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[[Category: CYI]]
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== Evolutionary Conservation ==
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[[Category: FE]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: MG]]
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Check<jmol>
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[[Category: NO]]
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<jmolCheckbox>
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[[Category: complex]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cz/2cz6_consurf.spt"</scriptWhenChecked>
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[[Category: cysteine-sulfenic acid]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: cysteine-sulfinic acid]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: hydration]]
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</jmolCheckbox>
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[[Category: national project on protein structural and functional analyses]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cz6 ConSurf].
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[[Category: nitrile]]
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<div style="clear:both"></div>
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[[Category: nppsfa]]
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[[Category: photo-reactive]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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[[Category: substrate analogue]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:53:52 2008''
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==See Also==
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*[[Nitrile hydratase|Nitrile hydratase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rhodococcus erythropolis]]
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[[Category: Hashimoto K]]
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[[Category: Kamiya N]]
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[[Category: Kawano Y]]
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[[Category: Nojiri M]]

Current revision

Complex of Inactive Fe-type NHase with Cyclohexyl isocyanide

PDB ID 2cz6

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