1xaw

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{{STRUCTURE_1xaw| PDB=1xaw | SCENE= }}
 
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===crystal structure of the cytoplasmic distal C-terminal domain of occludin===
 
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{{ABSTRACT_PUBMED_16081103}}
 
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==Disease==
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==crystal structure of the cytoplasmic distal C-terminal domain of occludin==
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[[http://www.uniprot.org/uniprot/OCLN_HUMAN OCLN_HUMAN]] Defects in OCLN are the cause of band-like calcification with simplified gyration and polymicrogyria (BLCPMG) [MIM:[http://omim.org/entry/251290 251290]]; also known as pseudo-TORCH syndrome. BLCPMG is a neurologic disorder with characteristic clinical and neuroradiologic features that mimic intrauterine TORCH infection in the absence of evidence of infection. Affected individuals have congenital microcephaly, intracranial calcifications, and severe developmental delay.<ref>PMID:20727516</ref>
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<StructureSection load='1xaw' size='340' side='right'caption='[[1xaw]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[1xaw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XAW FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/OCLN_HUMAN OCLN_HUMAN]] May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions.<ref>PMID:19114660</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xaw OCA], [https://pdbe.org/1xaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xaw RCSB], [https://www.ebi.ac.uk/pdbsum/1xaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xaw ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1xaw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAW OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/OCLN_HUMAN OCLN_HUMAN] Defects in OCLN are the cause of band-like calcification with simplified gyration and polymicrogyria (BLCPMG) [MIM:[https://omim.org/entry/251290 251290]; also known as pseudo-TORCH syndrome. BLCPMG is a neurologic disorder with characteristic clinical and neuroradiologic features that mimic intrauterine TORCH infection in the absence of evidence of infection. Affected individuals have congenital microcephaly, intracranial calcifications, and severe developmental delay.<ref>PMID:20727516</ref>
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==Reference==
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== Function ==
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<ref group="xtra">PMID:016081103</ref><references group="xtra"/><references/>
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[https://www.uniprot.org/uniprot/OCLN_HUMAN OCLN_HUMAN] May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions.<ref>PMID:19114660</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/1xaw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xaw ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Anderson, J M.]]
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[[Category: Large Structures]]
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[[Category: Fanning, A S.]]
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[[Category: Anderson JM]]
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[[Category: Lavie, A.]]
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[[Category: Fanning AS]]
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[[Category: Li, Y.]]
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[[Category: Lavie A]]
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[[Category: Cell adhesion]]
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[[Category: Li Y]]
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[[Category: Coiled-coil]]
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Current revision

crystal structure of the cytoplasmic distal C-terminal domain of occludin

PDB ID 1xaw

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