4f3i
From Proteopedia
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| - | {{STRUCTURE_4f3i| PDB=4f3i | SCENE= }} | ||
| - | ===Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor=== | ||
| - | {{ABSTRACT_PUBMED_22645123}} | ||
| - | == | + | ==Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor== |
| - | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN | + | <StructureSection load='4f3i' size='340' side='right'caption='[[4f3i]], [[Resolution|resolution]] 1.40Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4f3i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F3I FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0S6:METHYL+[(6S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-6-YL]ACETATE'>0S6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f3i OCA], [https://pdbe.org/4f3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f3i RCSB], [https://www.ebi.ac.uk/pdbsum/4f3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f3i ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | <references | + | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Joshua J]] |
| - | [[Category: | + | [[Category: Plotnikov AN]] |
| - | [[Category: | + | [[Category: Zhou M-M]] |
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Current revision
Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor
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