2k86

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{{STRUCTURE_2k86| PDB=2k86 | SCENE= }}
 
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===Solution Structure of FOXO3a Forkhead domain===
 
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{{ABSTRACT_PUBMED_18824006}}
 
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==Disease==
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==Solution Structure of FOXO3a Forkhead domain==
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[[http://www.uniprot.org/uniprot/FOXO3_HUMAN FOXO3_HUMAN]] Note=A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6;11)(q21;q23) with MLL/HRX.
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<StructureSection load='2k86' size='340' side='right'caption='[[2k86]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2k86]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K86 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k86 OCA], [https://pdbe.org/2k86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k86 RCSB], [https://www.ebi.ac.uk/pdbsum/2k86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k86 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FOXO3_HUMAN FOXO3_HUMAN] Note=A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6;11)(q21;q23) with MLL/HRX.
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== Function ==
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[https://www.uniprot.org/uniprot/FOXO3_HUMAN FOXO3_HUMAN] Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.<ref>PMID:10102273</ref> <ref>PMID:16751106</ref> <ref>PMID:21329882</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/2k86_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k86 ConSurf].
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<div style="clear:both"></div>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/FOXO3_HUMAN FOXO3_HUMAN]] Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.<ref>PMID:10102273</ref><ref>PMID:16751106</ref><ref>PMID:21329882</ref>
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*[[FOX 3D structures|FOX 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[2k86]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K86 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:018824006</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ikura, M.]]
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[[Category: Large Structures]]
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[[Category: Li, G.]]
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[[Category: Ikura M]]
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[[Category: Marshall, C B.]]
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[[Category: Li G]]
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[[Category: Plevin, M J.]]
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[[Category: Marshall CB]]
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[[Category: Wang, F.]]
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[[Category: Plevin MJ]]
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[[Category: Activator]]
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[[Category: Wang F]]
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[[Category: Apoptosis]]
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[[Category: Dna binding domain]]
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[[Category: Dna binding protein]]
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[[Category: Dna-binding]]
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[[Category: Forkhead]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Proto-oncogene]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Winged-helix]]
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Current revision

Solution Structure of FOXO3a Forkhead domain

PDB ID 2k86

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