1tbi
From Proteopedia
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{{Theoretical_model}} | {{Theoretical_model}} | ||
| - | + | ==TERTIARY MODEL OF EXTRACELLULAR DOMAIN OF TYPE I RECEPTOR FOR TRANSFORMING GROWTH FACTOR-BETA, THEORETICAL MODEL== | |
| - | + | <StructureSection load='1tbi' size='340' side='right'caption='[[1tbi]]' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TBI FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tbi FirstGlance], [https://www.ebi.ac.uk/pdbsum/1tbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbi ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We have observed that the extracellular domain of T beta RI and protectin (CD59), an inhibitor of the membrane attack complex of complement, share structural features, a distinct spacing of ten cysteines and a C-terminal 'Cys-box'. Based on these common features and the recently determined NMR-structure of protectin, a three-dimensional model for the extracellular domain of T beta RI was constructed. After energy minimization and molecular dynamics simulation, a structure with four extending fingers (pes quattvordigitorum) and two clusters of charged residues was obtained. This model provides a view to the understanding of interactions between T beta RI, T beta RII and TGF beta during ligand recognition and signal transduction. | ||
| - | + | Extracellular domain of type I receptor for transforming growth factor-beta: molecular modelling using protectin (CD59) as a template.,Jokiranta TS, Tissari J, Teleman O, Meri S FEBS Lett. 1995 Nov 27;376(1-2):31-6. PMID:8521960<ref>PMID:8521960</ref> | |
| - | <ref | + | |
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 1tbi" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Theoretical Model]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Jokiranta, T S]] | [[Category: Jokiranta, T S]] | ||
[[Category: Meri, S]] | [[Category: Meri, S]] | ||
[[Category: Teleman, O]] | [[Category: Teleman, O]] | ||
[[Category: Tissari, J]] | [[Category: Tissari, J]] | ||
Current revision
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TERTIARY MODEL OF EXTRACELLULAR DOMAIN OF TYPE I RECEPTOR FOR TRANSFORMING GROWTH FACTOR-BETA, THEORETICAL MODEL
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