2d2r

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[[Image:2d2r.gif|left|200px]]<br /><applet load="2d2r" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2d2r, resolution 1.88&Aring;" />
 
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'''Crystal structure of Helicobacter pylori Undecaprenyl Pyrophosphate Synthase'''<br />
 
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==About this Structure==
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==Crystal structure of Helicobacter pylori Undecaprenyl Pyrophosphate Synthase==
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2D2R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Active as [http://en.wikipedia.org/wiki/Di-trans,poly-cis-decaprenylcistransferase Di-trans,poly-cis-decaprenylcistransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.31 2.5.1.31] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D2R OCA].
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<StructureSection load='2d2r' size='340' side='right'caption='[[2d2r]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
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[[Category: Di-trans,poly-cis-decaprenylcistransferase]]
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== Structural highlights ==
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[[Category: Helicobacter pylori]]
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<table><tr><td colspan='2'>[[2d2r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D2R FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
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[[Category: Chen, C L.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d2r OCA], [https://pdbe.org/2d2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d2r RCSB], [https://www.ebi.ac.uk/pdbsum/2d2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d2r ProSAT]</span></td></tr>
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[[Category: Cheng, Y L.]]
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</table>
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[[Category: Cheng, Y S.]]
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== Function ==
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[[Category: Guo, R T.]]
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[https://www.uniprot.org/uniprot/ISPT_HELPY ISPT_HELPY] Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
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[[Category: Ko, T P.]]
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== Evolutionary Conservation ==
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[[Category: Kuo, C J.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Liang, P H.]]
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Check<jmol>
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[[Category: Wang, A H.J.]]
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<jmolCheckbox>
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[[Category: prenyl]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/2d2r_consurf.spt"</scriptWhenChecked>
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[[Category: prenyltransferase]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: undecaprenyl]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d2r ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Helicobacter pylori colonizes the human gastric epithelium and causes diseases such as gastritis, peptic ulcers, and stomach cancer. Undecaprenyl pyrophosphate synthase (UPPS), which catalyzes consecutive condensation reactions of farnesyl pyrophosphate with eight isopentenyl pyrophosphate to form lipid carrier for bacterial peptidoglycan biosynthesis, represents a potential target for developing new antibiotics. In this study, we solved the crystal structure of H. pylori UPPS and performed virtual screening of inhibitors from a library of 58,635 compounds. Two hits were found to exhibit differential activities against Helicobacter pylori and Escherichia coli UPPS, giving the possibility of developing antibiotics specially targeting pathogenic H. pylori without killing the intestinal E. coli.
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:54:47 2008''
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Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases.,Kuo CJ, Guo RT, Lu IL, Liu HG, Wu SY, Ko TP, Wang AH, Liang PH J Biomed Biotechnol. 2008;2008:841312. PMID:18382620<ref>PMID:18382620</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2d2r" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Undecaprenyl pyrophosphate synthase|Undecaprenyl pyrophosphate synthase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Helicobacter pylori]]
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[[Category: Large Structures]]
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[[Category: Chen CL]]
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[[Category: Cheng YL]]
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[[Category: Cheng YS]]
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[[Category: Guo RT]]
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[[Category: Ko TP]]
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[[Category: Kuo CJ]]
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[[Category: Liang PH]]
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[[Category: Wang AH-J]]

Current revision

Crystal structure of Helicobacter pylori Undecaprenyl Pyrophosphate Synthase

PDB ID 2d2r

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