2d47

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[[Image:2d47.gif|left|200px]]<br /><applet load="2d47" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2d47, resolution 2.000&Aring;" />
 
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'''MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA'''<br />
 
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==Overview==
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==MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA==
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We have determined the crystal structure of the dodecamer d(CCCCCGCGGGGG), showing for the first time a complete turn of A-DNA. It has average structural parameters similar to those determined in fibres. Nevertheless it shows a considerable local variation in structure which is in part associated with the presence of a bound spermine molecule. We conclude that the local DNA conformation does not only depend on the base sequence, but may be strongly modified upon interaction with other molecules. In particular, the CpG sequence, which is found in hypersensitive regions of the genome, appears to be able to easily change its conformation under external influences.
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<StructureSection load='2d47' size='340' side='right'caption='[[2d47]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2d47]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D47 FirstGlance]. <br>
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2D47 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=SPM:'>SPM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D47 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d47 OCA], [https://pdbe.org/2d47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d47 RCSB], [https://www.ebi.ac.uk/pdbsum/2d47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d47 ProSAT]</span></td></tr>
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Molecular structure of a complete turn of A-DNA., Verdaguer N, Aymami J, Fernandez-Forner D, Fita I, Coll M, Huynh-Dinh T, Igolen J, Subirana JA, J Mol Biol. 1991 Sep 20;221(2):623-35. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1920437 1920437]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Aymami, J.]]
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</StructureSection>
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[[Category: Coll, M.]]
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[[Category: Large Structures]]
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[[Category: Fernandez-Forner, D.]]
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[[Category: Aymami J]]
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[[Category: Fita, I.]]
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[[Category: Coll M]]
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[[Category: Huynh-Dinh, T.]]
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[[Category: Fernandez-Forner D]]
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[[Category: Igolen, J.]]
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[[Category: Fita I]]
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[[Category: Subirana, J A.]]
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[[Category: Huynh-Dinh T]]
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[[Category: Verdaguer, N.]]
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[[Category: Igolen J]]
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[[Category: SPM]]
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[[Category: Subirana JA]]
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[[Category: a-dna]]
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[[Category: Verdaguer N]]
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[[Category: double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:55:12 2008''
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Current revision

MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA

PDB ID 2d47

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