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4h0w

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{{STRUCTURE_4h0w| PDB=4h0w | SCENE= }}
 
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===Bismuth bound human serum transferrin===
 
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{{ABSTRACT_PUBMED_23256035}}
 
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==Disease==
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==Bismuth bound human serum transferrin==
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[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[http://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref><ref>PMID:15466165</ref>
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<StructureSection load='4h0w' size='340' side='right'caption='[[4h0w]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4h0w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H0W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BS3:BISMUTH(III)+ION'>BS3</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NTA:NITRILOTRIACETIC+ACID'>NTA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h0w OCA], [https://pdbe.org/4h0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h0w RCSB], [https://www.ebi.ac.uk/pdbsum/4h0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h0w ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
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*[[Transferrin 3D structures|Transferrin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[4h0w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H0W OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hao, Q.]]
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[[Category: Large Structures]]
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[[Category: Sun, H.]]
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[[Category: Hao Q]]
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[[Category: Wang, M.]]
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[[Category: Sun H]]
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[[Category: Yang, N.]]
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[[Category: Wang M]]
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[[Category: Zhang, H.]]
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[[Category: Yang N]]
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[[Category: Bismuth]]
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[[Category: Zhang H]]
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[[Category: Iron transporter]]
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[[Category: Metal transport]]
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Current revision

Bismuth bound human serum transferrin

PDB ID 4h0w

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