2lh8

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{{STRUCTURE_2lh8| PDB=2lh8 | SCENE= }}
 
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===Syrian hamster prion protein with thiamine===
 
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{{ABSTRACT_PUBMED_21848803}}
 
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==Disease==
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==Syrian hamster prion protein with thiamine==
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[[http://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
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<StructureSection load='2lh8' size='340' side='right'caption='[[2lh8]]' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[2lh8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesocricetus_auratus Mesocricetus auratus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LH8 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).<ref>PMID:19059915</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VIB:3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM'>VIB</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lh8 OCA], [https://pdbe.org/2lh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lh8 RCSB], [https://www.ebi.ac.uk/pdbsum/2lh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lh8 ProSAT]</span></td></tr>
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[[2lh8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesocricetus_auratus Mesocricetus auratus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LH8 OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
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== Function ==
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[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).<ref>PMID:19059915</ref>
==See Also==
==See Also==
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*[[Prion|Prion]]
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*[[Prion 3D structures|Prion 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021848803</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mesocricetus auratus]]
[[Category: Mesocricetus auratus]]
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[[Category: Abera, A.]]
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[[Category: Abera A]]
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[[Category: Berjanskii, M.]]
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[[Category: Berjanskii M]]
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[[Category: Bjorndahl, T C.]]
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[[Category: Bjorndahl TC]]
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[[Category: Cashman, N R.]]
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[[Category: Cashman NR]]
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[[Category: Dong, Y Wei.]]
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[[Category: Gibbs E]]
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[[Category: Gibbs, E.]]
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[[Category: Hau D]]
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[[Category: Hau, D.]]
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[[Category: Huang A]]
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[[Category: Huang, A.]]
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[[Category: Ladner C]]
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[[Category: Ladner, C.]]
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[[Category: Lee R]]
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[[Category: Lee, R.]]
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[[Category: Li L]]
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[[Category: Li, L.]]
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[[Category: Perez-Pineiro R]]
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[[Category: Perez-Pineiro, R.]]
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[[Category: Wei Dong Y]]
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[[Category: Wishart, D.]]
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[[Category: Wishart D]]
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[[Category: Membrane protein]]
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[[Category: Prion]]
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[[Category: Thiamine]]
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Current revision

Syrian hamster prion protein with thiamine

PDB ID 2lh8

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