2yl2

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{{STRUCTURE_2yl2| PDB=2yl2 | SCENE= }}
 
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===CRYSTAL STRUCTURE OF HUMAN ACETYL-COA CARBOXYLASE 1, BIOTIN CARBOXYLASE (BC) DOMAIN===
 
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==Disease==
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==Crystal structure of human acetyl-CoA carboxylase 1, biotin carboxylase (BC) domain==
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[[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[http://omim.org/entry/613933 613933]]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref>
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<StructureSection load='2yl2' size='340' side='right'caption='[[2yl2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[2yl2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YL2 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yl2 OCA], [https://pdbe.org/2yl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yl2 RCSB], [https://www.ebi.ac.uk/pdbsum/2yl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yl2 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2yl2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YL2 OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[https://omim.org/entry/613933 613933]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref>
==See Also==
==See Also==
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*[[Biotin carboxylase|Biotin carboxylase]]
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*[[Acetyl-CoA carboxylase 3D structures|Acetyl-CoA carboxylase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Beltrami, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Beltrami A]]
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[[Category: Delft, F Von.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Froese, D S.]]
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[[Category: Froese DS]]
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[[Category: Krojer, T.]]
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[[Category: Krojer T]]
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[[Category: Krysztofinska, E.]]
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[[Category: Krysztofinska E]]
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[[Category: Muniz, J R.C.]]
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[[Category: Muniz JRC]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann U]]
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[[Category: Vollmar, M.]]
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[[Category: Vollmar M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Yue, W W.]]
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[[Category: Yue WW]]
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[[Category: Ligase]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of human acetyl-CoA carboxylase 1, biotin carboxylase (BC) domain

PDB ID 2yl2

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