3siu

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{{STRUCTURE_3siu| PDB=3siu | SCENE= }}
 
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===Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, monomeric form===
 
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{{ABSTRACT_PUBMED_21784869}}
 
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==Disease==
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==Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, monomeric form==
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[[http://www.uniprot.org/uniprot/PRP31_HUMAN PRP31_HUMAN]] Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11) [MIM:[http://omim.org/entry/600138 600138]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP11 inheritance is autosomal dominant.<ref>PMID:17412961</ref><ref>PMID:12444105</ref><ref>PMID:11545739</ref><ref>PMID:8808602</ref><ref>PMID:12923864</ref>
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<StructureSection load='3siu' size='340' side='right'caption='[[3siu]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3siu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SIU FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/NH2L1_HUMAN NH2L1_HUMAN]] Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.<ref>PMID:10545122</ref><ref>PMID:17412961</ref> [[http://www.uniprot.org/uniprot/PRP31_HUMAN PRP31_HUMAN]] Involved in pre-mRNA splicing. Required for U4/U6.U5 tri-snRNP formation.<ref>PMID:11867543</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.626&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3siu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3siu OCA], [https://pdbe.org/3siu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3siu RCSB], [https://www.ebi.ac.uk/pdbsum/3siu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3siu ProSAT]</span></td></tr>
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[[3siu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SIU OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NH2L1_HUMAN NH2L1_HUMAN] Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.<ref>PMID:10545122</ref> <ref>PMID:17412961</ref>
==See Also==
==See Also==
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*[[Nucleoprotein|Nucleoprotein]]
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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*[[Pre-mRNA-splicing factor|Pre-mRNA-splicing factor]]
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*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021784869</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ghalei, H.]]
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[[Category: Large Structures]]
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[[Category: Liu, S.]]
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[[Category: Ghalei H]]
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[[Category: Luhrmann, R.]]
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[[Category: Liu S]]
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[[Category: Wahl, M C.]]
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[[Category: Luhrmann R]]
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[[Category: Major and minor spliceosome]]
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[[Category: Wahl MC]]
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[[Category: Nucleus]]
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[[Category: Pre-mrna splicing]]
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[[Category: Rna-binding protein]]
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[[Category: Rna-protein complex]]
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[[Category: Splicing-rna complex]]
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[[Category: U4 snrna]]
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[[Category: U4 snrnp and u4atac snrnp]]
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Current revision

Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, monomeric form

PDB ID 3siu

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