1gtq
From Proteopedia
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| - | {{STRUCTURE_1gtq| PDB=1gtq | SCENE= }} | ||
| - | ===6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE=== | ||
| - | {{ABSTRACT_PUBMED_8137809}} | ||
| - | == | + | ==6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE== |
| - | [[http://www.uniprot.org/uniprot/PTPS_RAT PTPS_RAT | + | <StructureSection load='1gtq' size='340' side='right'caption='[[1gtq]], [[Resolution|resolution]] 2.30Å' scene=''> |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[1gtq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. The August 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Tetrahydrobiopterin Biosynthesis'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_8 10.2210/rcsb_pdb/mom_2015_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GTQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GTQ FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gtq OCA], [https://pdbe.org/1gtq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gtq RCSB], [https://www.ebi.ac.uk/pdbsum/1gtq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gtq ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | + | == Disease == | |
| - | + | [https://www.uniprot.org/uniprot/PTPS_RAT PTPS_RAT] Note=Deficiency leads to phenylketonuria. | |
| - | < | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PTPS_RAT PTPS_RAT] Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. |
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/1gtq_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gtq ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Rattus rattus]] | [[Category: Rattus rattus]] | ||
| - | [[Category: Buergisser | + | [[Category: Tetrahydrobiopterin Biosynthesis]] |
| - | [[Category: Heizmann | + | [[Category: Buergisser D]] |
| - | [[Category: Huber | + | [[Category: Heizmann CW]] |
| - | [[Category: Nar | + | [[Category: Huber R]] |
| - | [[Category: Thoeny | + | [[Category: Nar H]] |
| - | + | [[Category: Thoeny B]] | |
| - | + | ||
| - | + | ||
Current revision
6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE
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