This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1a1x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:26, 7 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_1a1x| PDB=1a1x | SCENE= }}
 
-
===CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES===
 
-
{{ABSTRACT_PUBMED_9520380}}
 
-
==Disease==
+
==CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES==
-
[[http://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.
+
<StructureSection load='1a1x' size='340' side='right'caption='[[1a1x]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==Function==
+
<table><tr><td colspan='2'>[[1a1x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A1X FirstGlance]. <br>
-
[[http://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a1x OCA], [https://pdbe.org/1a1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a1x RCSB], [https://www.ebi.ac.uk/pdbsum/1a1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a1x ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[1a1x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1X OCA].
+
== Disease ==
-
 
+
[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.
-
==Reference==
+
== Function ==
-
<ref group="xtra">PMID:009520380</ref><ref group="xtra">PMID:019113835</ref><references group="xtra"/><references/>
+
[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/1a1x_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a1x ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Croce, C M.]]
+
[[Category: Large Structures]]
-
[[Category: Dubois, G C.]]
+
[[Category: Croce CM]]
-
[[Category: Fu, Z Q.]]
+
[[Category: Dubois GC]]
-
[[Category: Harrison, R W.]]
+
[[Category: Fu ZQ]]
-
[[Category: Kulikovskaya, I.]]
+
[[Category: Harrison RW]]
-
[[Category: Rothstein, J.]]
+
[[Category: Kulikovskaya I]]
-
[[Category: Song, S P.]]
+
[[Category: Rothstein J]]
-
[[Category: Virgilio, L.]]
+
[[Category: Song SP]]
-
[[Category: Weber, I T.]]
+
[[Category: Virgilio L]]
-
[[Category: Mtcp-1]]
+
[[Category: Weber IT]]
-
[[Category: Oncogene involved in t cell malignancy]]
+
-
[[Category: Proto-oncogene]]
+

Current revision

CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES

PDB ID 1a1x

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1a1x"
Personal tools