3bfo

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{{STRUCTURE_3bfo| PDB=3bfo | SCENE= }}
 
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===Crystal structure of Ig-like C2-type 2 domain of the human Mucosa-associated lymphoid tissue lymphoma translocation protein 1===
 
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{{ABSTRACT_PUBMED_018164727}}
 
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==Disease==
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==Crystal structure of Ig-like C2-type 2 domain of the human Mucosa-associated lymphoid tissue lymphoma translocation protein 1==
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[[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
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<StructureSection load='3bfo' size='340' side='right'caption='[[3bfo]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3bfo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BFO FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref><ref>PMID:14695475</ref><ref>PMID:18264101</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bfo OCA], [https://pdbe.org/3bfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bfo RCSB], [https://www.ebi.ac.uk/pdbsum/3bfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bfo ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3bfo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BFO OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
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==Reference==
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== Function ==
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<ref group="xtra">PMID:018164727</ref><references group="xtra"/><references/>
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[https://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref> <ref>PMID:14695475</ref> <ref>PMID:18264101</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bf/3bfo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bfo ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Akutsu, M.]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Akutsu M]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Dhe-Paganon, S.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M.]]
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[[Category: Dhe-Paganon S]]
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[[Category: Li, Y.]]
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[[Category: Edwards AM]]
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[[Category: Littler, D R.]]
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[[Category: Li Y]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Littler DR]]
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[[Category: Walker, J R.]]
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[[Category: Walker JR]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Hydrolase]]
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[[Category: Immunoglobulin domain]]
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[[Category: Nucleus]]
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[[Category: Protease]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Ubl conjugation pathway]]
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Current revision

Crystal structure of Ig-like C2-type 2 domain of the human Mucosa-associated lymphoid tissue lymphoma translocation protein 1

PDB ID 3bfo

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