3ndq

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{{STRUCTURE_3ndq| PDB=3ndq | SCENE= }}
 
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===Structure of Human TFIIS Domain II===
 
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==Disease==
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==Structure of Human TFIIS Domain II==
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[[http://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN]] Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.
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<StructureSection load='3ndq' size='340' side='right'caption='[[3ndq]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3ndq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NDQ FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN]] Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.933&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ndq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ndq OCA], [https://pdbe.org/3ndq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ndq RCSB], [https://www.ebi.ac.uk/pdbsum/3ndq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ndq ProSAT]</span></td></tr>
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[[3ndq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NDQ OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN] Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.
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== Function ==
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[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN] Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
==See Also==
==See Also==
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*[[Elongation factor|Elongation factor]]
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*[[Elongation factor 3D structures|Elongation factor 3D structures]]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Averell, G.]]
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[[Category: Large Structures]]
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[[Category: Hou, J.]]
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[[Category: Averell G]]
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[[Category: Hu, X P.]]
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[[Category: Hou J]]
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[[Category: Luo, H.]]
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[[Category: Hu XP]]
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[[Category: Ye, X Y.]]
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[[Category: Luo H]]
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[[Category: Helix bundle]]
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[[Category: Ye XY]]
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[[Category: Transcription]]
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Current revision

Structure of Human TFIIS Domain II

PDB ID 3ndq

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