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3uv5

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{{STRUCTURE_3uv5| PDB=3uv5 | SCENE= }}
 
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===Crystal Structure of the tandem bromodomains of human Transcription initiation factor TFIID subunit 1 (TAF1)===
 
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{{ABSTRACT_PUBMED_22464331}}
 
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==Disease==
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==Crystal Structure of the tandem bromodomains of human Transcription initiation factor TFIID subunit 1 (TAF1)==
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[[http://www.uniprot.org/uniprot/TAF1_HUMAN TAF1_HUMAN]] Defects in TAF1 are the cause of dystonia type 3 (DYT3) [MIM:[http://omim.org/entry/314250 314250]]; also called X-linked dystonia-parkinsonism (XDP). DYT3 is a X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. Its prevalence is high in the Philippines. DYT3 has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease.<ref>PMID:12928496</ref><ref>PMID:17273961</ref>
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<StructureSection load='3uv5' size='340' side='right'caption='[[3uv5]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3uv5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UV5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv5 OCA], [https://pdbe.org/3uv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uv5 RCSB], [https://www.ebi.ac.uk/pdbsum/3uv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uv5 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TAF1_HUMAN TAF1_HUMAN] Defects in TAF1 are the cause of dystonia type 3 (DYT3) [MIM:[https://omim.org/entry/314250 314250]; also called X-linked dystonia-parkinsonism (XDP). DYT3 is a X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. Its prevalence is high in the Philippines. DYT3 has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease.<ref>PMID:12928496</ref> <ref>PMID:17273961</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TAF1_HUMAN TAF1_HUMAN] Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.<ref>PMID:2038334</ref> <ref>PMID:8450888</ref> <ref>PMID:8625415</ref> <ref>PMID:9660973</ref> <ref>PMID:9858607</ref> <ref>PMID:11278496</ref> <ref>PMID:15053879</ref>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/TAF1_HUMAN TAF1_HUMAN]] Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.<ref>PMID:2038334</ref><ref>PMID:8450888</ref><ref>PMID:8625415</ref><ref>PMID:9660973</ref><ref>PMID:9858607</ref><ref>PMID:11278496</ref><ref>PMID:15053879</ref>
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*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3uv5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV5 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:022464331</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Delft, F von.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Felletar I]]
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[[Category: Felletar, I.]]
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[[Category: Filippakopoulos P]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O.]]
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[[Category: Keates T]]
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[[Category: Keates, T.]]
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[[Category: Knapp S]]
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[[Category: Knapp, S.]]
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[[Category: Muniz J]]
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[[Category: Muniz, J.]]
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[[Category: Picaud S]]
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[[Category: Picaud, S.]]
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[[Category: Weigelt J]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: Cell cycle gene 1 protein]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Taf1]]
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[[Category: Tandem bromodomain]]
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[[Category: Tbp-associated factor 250 kda]]
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[[Category: Tfii-250]]
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[[Category: Transcription]]
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[[Category: Transcription initiation factor tfiid 250 kda subunit]]
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Current revision

Crystal Structure of the tandem bromodomains of human Transcription initiation factor TFIID subunit 1 (TAF1)

PDB ID 3uv5

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