1nav

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{{STRUCTURE_1nav| PDB=1nav | SCENE= }}
 
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===Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1===
 
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{{ABSTRACT_PUBMED_12699376}}
 
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==Disease==
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==Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1==
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[[http://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN]] Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:[http://omim.org/entry/614450 614450]]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.<ref>PMID:22168587</ref>
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<StructureSection load='1nav' size='340' side='right'caption='[[1nav]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nav]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NAV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IH5:{3,5-DICHLORO-4-[4-HYDROXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}ACETIC+ACID'>IH5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nav OCA], [https://pdbe.org/1nav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nav RCSB], [https://www.ebi.ac.uk/pdbsum/1nav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nav ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN] Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:[https://omim.org/entry/614450 614450]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.<ref>PMID:22168587</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN] Nuclear hormone receptor. High affinity receptor for triiodothyronine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/na/1nav_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nav ConSurf].
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<div style="clear:both"></div>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN]] Nuclear hormone receptor. High affinity receptor for triiodothyronine.
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*[[Thyroid hormone receptor 3D structures|Thyroid hormone receptor 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[1nav]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAV OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:012699376</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bladh, L G.]]
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[[Category: Large Structures]]
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[[Category: Collazo, A M.Garcia.]]
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[[Category: Bladh LG]]
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[[Category: Garg, N.]]
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[[Category: Garcia Collazo AM]]
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[[Category: George, R.]]
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[[Category: Garg N]]
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[[Category: Grover, G.]]
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[[Category: George R]]
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[[Category: Husman, B.]]
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[[Category: Grover G]]
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[[Category: Koehler, K.]]
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[[Category: Husman B]]
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[[Category: Li, Y L.]]
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[[Category: Koehler K]]
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[[Category: Litten, C.]]
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[[Category: Li YL]]
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[[Category: Ljunggren, J.]]
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[[Category: Litten C]]
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[[Category: Malm, J.]]
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[[Category: Ljunggren J]]
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[[Category: Mellin, C.]]
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[[Category: Malm J]]
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[[Category: Mellstrom, K.]]
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[[Category: Mellin C]]
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[[Category: Persson, K.]]
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[[Category: Mellstrom K]]
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[[Category: Sleph, P G.]]
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[[Category: Persson K]]
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[[Category: Ye, L.]]
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[[Category: Sleph PG]]
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[[Category: Complex]]
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[[Category: Ye L]]
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[[Category: Ligand]]
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[[Category: Membrane protein]]
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[[Category: Nuclear receptor]]
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[[Category: Thyroid receptor]]
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Current revision

Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1

PDB ID 1nav

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