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1pr9

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{{STRUCTURE_1pr9| PDB=1pr9 | SCENE= }}
 
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===Human L-Xylulose Reductase Holoenzyme===
 
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{{ABSTRACT_PUBMED_15103634}}
 
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==Disease==
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==Human L-Xylulose Reductase Holoenzyme==
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[[http://www.uniprot.org/uniprot/DCXR_HUMAN DCXR_HUMAN]] Note=The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose.
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<StructureSection load='1pr9' size='340' side='right'caption='[[1pr9]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[1pr9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PR9 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/DCXR_HUMAN DCXR_HUMAN]] Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HP:DIHYDROGENPHOSPHATE+ION'>2HP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pr9 OCA], [https://pdbe.org/1pr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1pr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pr9 ProSAT]</span></td></tr>
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[[1pr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PR9 OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/DCXR_HUMAN DCXR_HUMAN] Note=The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose.
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<ref group="xtra">PMID:015103634</ref><ref group="xtra">PMID:012136162</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/DCXR_HUMAN DCXR_HUMAN] Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/1pr9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pr9 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: L-xylulose reductase]]
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[[Category: Large Structures]]
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[[Category: Carbone, V.]]
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[[Category: Carbone V]]
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[[Category: Chung, R P.T.]]
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[[Category: Chung RP-T]]
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[[Category: Darmanin, C.]]
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[[Category: Darmanin C]]
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[[Category: El-Kabbani, O.]]
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[[Category: El-Kabbani O]]
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[[Category: Hara, A.]]
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[[Category: Hara A]]
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[[Category: Ishikura, S.]]
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[[Category: Ishikura S]]
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[[Category: Usami, N.]]
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[[Category: Usami N]]
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[[Category: Dinucleotide binding domain]]
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[[Category: Oxidoreductase]]
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[[Category: Short chain dehydrogenase/reductase]]
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Current revision

Human L-Xylulose Reductase Holoenzyme

PDB ID 1pr9

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