3fb2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:32, 6 December 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3fb2| PDB=3fb2 | SCENE= }}
 
-
===Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.===
 
-
==Disease==
+
==Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.==
-
[[http://www.uniprot.org/uniprot/SPTA2_HUMAN SPTA2_HUMAN]] Defects in SPTAN1 are the cause of epileptic encephalopathy early infantile type 5 (EIEE5) [MIM:[http://omim.org/entry/613477 613477]]. EIEE5 is a disorder characterized by seizures associated with hypsarrhythmia profound mental retardation with lack of visual attention and speech development, as well as spastic quadriplegia.<ref>PMID:20493457</ref>
+
<StructureSection load='3fb2' size='340' side='right'caption='[[3fb2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==Function==
+
<table><tr><td colspan='2'>[[3fb2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FB2 FirstGlance]. <br>
-
[[http://www.uniprot.org/uniprot/SPTA2_HUMAN SPTA2_HUMAN]] Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fb2 OCA], [https://pdbe.org/3fb2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fb2 RCSB], [https://www.ebi.ac.uk/pdbsum/3fb2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fb2 ProSAT], [https://www.topsan.org/Proteins/NESGC/3fb2 TOPSAN]</span></td></tr>
-
[[3fb2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB2 OCA].
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/SPTN1_HUMAN SPTN1_HUMAN] West syndrome. The disease is caused by mutations affecting the gene represented in this entry.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SPTN1_HUMAN SPTN1_HUMAN] Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
==See Also==
==See Also==
-
*[[Spectrin|Spectrin]]
+
*[[Spectrin 3D structures|Spectrin 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<references group="xtra"/><references/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Acton, T B.]]
+
[[Category: Large Structures]]
-
[[Category: Ciccosanti, C.]]
+
[[Category: Acton TB]]
-
[[Category: Foote, E L.]]
+
[[Category: Ciccosanti C]]
-
[[Category: Hunt, J F.]]
+
[[Category: Foote EL]]
-
[[Category: Janjua, H.]]
+
[[Category: Hunt JF]]
-
[[Category: Montelione, G T.]]
+
[[Category: Janjua H]]
-
[[Category: NESG, Northeast Structural Genomics Consortium.]]
+
[[Category: Montelione GT]]
-
[[Category: Seetharaman, J.]]
+
[[Category: Seetharaman J]]
-
[[Category: Shastry, R.]]
+
[[Category: Shastry R]]
-
[[Category: Su, M.]]
+
[[Category: Su M]]
-
[[Category: Tong, L.]]
+
[[Category: Tong L]]
-
[[Category: Vorobiev, S M.]]
+
[[Category: Vorobiev SM]]
-
[[Category: Xiao, R.]]
+
[[Category: Xiao R]]
-
[[Category: Actin capping]]
+
-
[[Category: Actin-binding]]
+
-
[[Category: Brain spectrin]]
+
-
[[Category: Calmodulin-binding]]
+
-
[[Category: Cytoskeleton]]
+
-
[[Category: Fordrin alpha chain]]
+
-
[[Category: Hr5563a]]
+
-
[[Category: Nesg]]
+
-
[[Category: Non-erythroid alpha chain alpha-ii spectrin]]
+
-
[[Category: Northeast structural genomics consortium]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Protein structure initiative]]
+
-
[[Category: Psi-2]]
+
-
[[Category: Sh3 domain]]
+
-
[[Category: Spectrin alpha chain]]
+
-
[[Category: Spta2_human]]
+
-
[[Category: Sptan1]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural protein]]
+

Current revision

Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.

PDB ID 3fb2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3fb2"
Personal tools