2kzt

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{{Large structure}}
 
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{{STRUCTURE_2kzt| PDB=2kzt | SCENE= }}
 
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===Structure of the Tandem MA-3 Region of Pdcd4===
 
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{{ABSTRACT_PUBMED_21454508}}
 
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==Disease==
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==Structure of the Tandem MA-3 Region of Pdcd4==
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[[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Note=Decreases benign tumor development and malignant progression.
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<StructureSection load='2kzt' size='340' side='right'caption='[[2kzt]]' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[2kzt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZT FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/PDCD4_HUMAN PDCD4_HUMAN]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).<ref>PMID:16357133</ref><ref>PMID:16449643</ref><ref>PMID:17053147</ref><ref>PMID:18296639</ref><ref>PMID:19153607</ref><ref>PMID:19204291</ref> [[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.<ref>PMID:12482958</ref><ref>PMID:12894233</ref><ref>PMID:16024603</ref><ref>PMID:17060447</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzt OCA], [https://pdbe.org/2kzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzt RCSB], [https://www.ebi.ac.uk/pdbsum/2kzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzt ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2kzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZT OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/PDCD4_HUMAN PDCD4_HUMAN] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).<ref>PMID:16357133</ref> <ref>PMID:16449643</ref> <ref>PMID:17053147</ref> <ref>PMID:18296639</ref> <ref>PMID:19153607</ref> <ref>PMID:19204291</ref>
==See Also==
==See Also==
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*[[Cell death protein|Cell death protein]]
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*[[Cell death protein 3D structures|Cell death protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021454508</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Banerjee, S.]]
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[[Category: Banerjee S]]
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[[Category: Carr, M D.]]
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[[Category: Carr MD]]
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[[Category: Henry, A J.]]
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[[Category: Henry AJ]]
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[[Category: Klempnauer, K H.]]
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[[Category: Klempnauer KH]]
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[[Category: Muskett, F W.]]
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[[Category: Muskett FW]]
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[[Category: Oka, O.]]
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[[Category: Oka O]]
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[[Category: Schmedt, T.]]
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[[Category: Schmedt T]]
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[[Category: Strong, S L.]]
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[[Category: Strong SL]]
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[[Category: Veverka, V.]]
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[[Category: Veverka V]]
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[[Category: Waters, L C.]]
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[[Category: Waters LC]]
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[[Category: Apoptosis]]
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[[Category: Eif4a]]
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[[Category: Heat]]
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[[Category: Ma-3]]
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[[Category: Pdcd4]]
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Current revision

Structure of the Tandem MA-3 Region of Pdcd4

PDB ID 2kzt

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