2dnf
From Proteopedia
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| - | {{STRUCTURE_2dnf| PDB=2dnf | SCENE= }} | ||
| - | ===Solution structure of RSGI RUH-062, a DCX domain from human=== | ||
| - | == | + | ==Solution structure of RSGI RUH-062, a DCX domain from human== |
| - | [[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN | + | <StructureSection load='2dnf' size='340' side='right'caption='[[2dnf]]' scene=''> |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[2dnf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DNF FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnf OCA], [https://pdbe.org/2dnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dnf RCSB], [https://www.ebi.ac.uk/pdbsum/2dnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dnf ProSAT], [https://www.topsan.org/Proteins/RSGI/2dnf TOPSAN]</span></td></tr> | |
| - | == | + | </table> |
| - | [[ | + | == Disease == |
| - | + | [https://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:[https://omim.org/entry/600202 600202]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.<ref>PMID:16278297</ref> | |
| - | == | + | == Function == |
| - | <references | + | [https://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN] May be involved in neuronal migration during development of the cerebral neocortex (By similarity). |
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/2dnf_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dnf ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Hayashi | + | [[Category: Large Structures]] |
| - | [[Category: Hirota | + | [[Category: Hayashi F]] |
| - | [[Category: Nagashima | + | [[Category: Hirota H]] |
| - | [[Category: Ohashi | + | [[Category: Nagashima T]] |
| - | + | [[Category: Ohashi W]] | |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
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Current revision
Solution structure of RSGI RUH-062, a DCX domain from human
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