1fli

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{{STRUCTURE_1fli| PDB=1fli | SCENE= }}
 
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===DNA-BINDING DOMAIN OF FLI-1===
 
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{{ABSTRACT_PUBMED_7773776}}
 
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==Disease==
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==DNA-BINDING DOMAIN OF FLI-1==
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[[http://www.uniprot.org/uniprot/FLI1_HUMAN FLI1_HUMAN]] Defects in FLI1 are a cause of Ewing sarcoma (ES) [MIM:[http://omim.org/entry/612219 612219]]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1.
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<StructureSection load='1fli' size='340' side='right'caption='[[1fli]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1fli]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FLI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FLI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fli OCA], [https://pdbe.org/1fli PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fli RCSB], [https://www.ebi.ac.uk/pdbsum/1fli PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fli ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FLI1_HUMAN FLI1_HUMAN] Defects in FLI1 are a cause of Ewing sarcoma (ES) [MIM:[https://omim.org/entry/612219 612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1.
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== Function ==
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[https://www.uniprot.org/uniprot/FLI1_HUMAN FLI1_HUMAN] Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/1fli_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fli ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Members of the ets family of transcription factors share a conserved DNA-binding domain, the ets domain. By using multidimensional NMR, we have determined the structure of the ets domain of human Fli-1 in the DNA-bound form. It consists of three alpha-helices and a four-stranded beta-sheet, similar to structures of the class of helix-turn-helix DNA binding proteins first found in the catabolite activator protein of Escherichia coli. NMR and mutagenesis experiments suggest that in comparison to structurally related proteins, the ets domain uses a new variation of the helix-turn-helix motif for binding to DNA.
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==Function==
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Solution structure of the ets domain of Fli-1 when bound to DNA.,Liang H, Mao X, Olejniczak ET, Nettesheim DG, Yu L, Meadows RP, Thompson CB, Fesik SW Nat Struct Biol. 1994 Dec;1(12):871-5. PMID:7773776<ref>PMID:7773776</ref>
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[[http://www.uniprot.org/uniprot/FLI1_HUMAN FLI1_HUMAN]] Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[1fli]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FLI OCA].
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</div>
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<div class="pdbe-citations 1fli" style="background-color:#fffaf0;"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:007773776</ref><references group="xtra"/><references/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fesik, S W.]]
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[[Category: Large Structures]]
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[[Category: Liang, H.]]
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[[Category: Fesik SW]]
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[[Category: Mao, X.]]
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[[Category: Liang H]]
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[[Category: Meadows, R P.]]
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[[Category: Mao X]]
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[[Category: Nettesheim, D G.]]
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[[Category: Meadows RP]]
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[[Category: Olejniczak, E T.]]
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[[Category: Nettesheim DG]]
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[[Category: Thompson, C B.]]
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[[Category: Olejniczak ET]]
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[[Category: Yu, L.]]
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[[Category: Thompson CB]]
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[[Category: Transcription-dna complex]]
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[[Category: Yu L]]
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[[Category: Transcription/dna]]
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Current revision

DNA-BINDING DOMAIN OF FLI-1

PDB ID 1fli

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