We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
1p0t
From Proteopedia
(Difference between revisions)
proteopedia linkproteopedia link
|
|
| Line 1: |
Line 1: |
| - | {{STRUCTURE_1p0t| PDB=1p0t | SCENE= }}
| + | #REDIRECT [[4v46]] This PDB entry is obsolete and replaced by 4v46 |
| - | ===Crystal Structure of the BAFF-BAFF-R complex (part II)===
| + | |
| - | {{ABSTRACT_PUBMED_12715002}}
| + | |
| - | | + | |
| - | ==Disease==
| + | |
| - | [[http://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN]] Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:[http://omim.org/entry/613494 613494]]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:19666484</ref> | + | |
| - | | + | |
| - | ==Function==
| + | |
| - | [[http://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN]] B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.<ref>PMID:11591325</ref><ref>PMID:12387744</ref>
| + | |
| - | | + | |
| - | ==About this Structure==
| + | |
| - | [[1p0t]] is a 60 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P0T OCA].
| + | |
| - | | + | |
| - | ==Reference==
| + | |
| - | <ref group="xtra">PMID:012715002</ref><references group="xtra"/><references/>
| + | |
| - | [[Category: Homo sapiens]]
| + | |
| - | [[Category: Kim, H M.]]
| + | |
| - | [[Category: Kim, Y S.]]
| + | |
| - | [[Category: Lee, H.]]
| + | |
| - | [[Category: Lee, J O.]]
| + | |
| - | [[Category: Lee, M E.]]
| + | |
| - | [[Category: Paik, S G.]]
| + | |
| - | [[Category: Shin, D R.]]
| + | |
| - | [[Category: Yoo, O J.]]
| + | |
| - | [[Category: Yu, K S.]]
| + | |
| - | [[Category: Baff]]
| + | |
| - | [[Category: Baff-r]]
| + | |
| - | [[Category: Bly]]
| + | |
| - | [[Category: Br-3]]
| + | |
| - | [[Category: Protein binding]]
| + | |
| - | [[Category: Stall]]
| + | |
Current revision
- REDIRECT 4v46 This PDB entry is obsolete and replaced by 4v46
