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3sek

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{{STRUCTURE_3sek| PDB=3sek | SCENE= }}
 
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===Crystal Structure of the Myostatin:Follistatin-like 3 Complex===
 
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{{ABSTRACT_PUBMED_022052913}}
 
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==Disease==
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==Crystal Structure of the Myostatin:Follistatin-like 3 Complex==
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[[http://www.uniprot.org/uniprot/FSTL3_HUMAN FSTL3_HUMAN]] Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.
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<StructureSection load='3sek' size='340' side='right'caption='[[3sek]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3sek]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SEK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.401&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sek OCA], [https://pdbe.org/3sek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sek RCSB], [https://www.ebi.ac.uk/pdbsum/3sek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sek ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GDF8_MOUSE GDF8_MOUSE] Acts specifically as a negative regulator of skeletal muscle growth.
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/GDF8_MOUSE GDF8_MOUSE]] Acts specifically as a negative regulator of skeletal muscle growth. [[http://www.uniprot.org/uniprot/FSTL3_HUMAN FSTL3_HUMAN]] Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.<ref>PMID:11948405</ref><ref>PMID:15451575</ref><ref>PMID:15574124</ref><ref>PMID:16336961</ref><ref>PMID:17868029</ref><ref>PMID:17878677</ref>
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*[[Follistatin|Follistatin]]
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*[[Growth differentiation factor 3D STRUCTURES|Growth differentiation factor 3D STRUCTURES]]
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==About this Structure==
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__TOC__
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[[3sek]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEK OCA].
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</StructureSection>
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Cash, J N.]]
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[[Category: Cash JN]]
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[[Category: Thompson, T B.]]
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[[Category: Thompson TB]]
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[[Category: Cystine knot motif]]
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[[Category: Disulfide linked dimer]]
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[[Category: Protein-protein complex]]
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[[Category: Signaling protein]]
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[[Category: Tb domain]]
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[[Category: Tgf-beta fold]]
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Current revision

Crystal Structure of the Myostatin:Follistatin-like 3 Complex

PDB ID 3sek

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