3zgx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:39, 9 May 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3zgx| PDB=3zgx | SCENE= }}
 
-
===Crystal structure of the kleisin-N SMC interface in prokaryotic condensin===
 
-
{{ABSTRACT_PUBMED_23353789}}
 
-
==Function==
+
==Crystal structure of the kleisin-N SMC interface in prokaryotic condensin==
-
[[http://www.uniprot.org/uniprot/SMC_BACSU SMC_BACSU]] Required for chromosome condensation and partitioning.<ref>PMID:9573042</ref><ref>PMID:9701812</ref> [[http://www.uniprot.org/uniprot/SCPA_BACSU SCPA_BACSU]] Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.[HAMAP-Rule:MF_01805]
+
<StructureSection load='3zgx' size='340' side='right'caption='[[3zgx]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3zgx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZGX FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgx OCA], [https://pdbe.org/3zgx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zgx RCSB], [https://www.ebi.ac.uk/pdbsum/3zgx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zgx ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SMC_BACSU SMC_BACSU] Required for chromosome condensation and partitioning.<ref>PMID:9573042</ref> <ref>PMID:9701812</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Eukaryotic structural maintenance of chromosomes (SMC)-kleisin complexes form large, ring-shaped assemblies that promote accurate chromosome segregation. Their asymmetric structural core comprises SMC heterodimers that associate with both ends of a kleisin subunit. However, prokaryotic condensin Smc-ScpAB is composed of symmetric Smc homodimers associated with the kleisin ScpA in a postulated symmetrical manner. Here, we demonstrate that Smc molecules have two distinct binding sites for ScpA. The N terminus of ScpA binds the Smc coiled coil, whereas the C terminus binds the Smc ATPase domain. We show that in Bacillus subtilis cells, an Smc dimer is bridged by a single ScpAB to generate asymmetric tripartite rings analogous to eukaryotic SMC complexes. We define a molecular mechanism that ensures asymmetric assembly, and we conclude that the basic architecture of SMC-kleisin rings evolved before the emergence of eukaryotes.
-
==About this Structure==
+
An asymmetric SMC-kleisin bridge in prokaryotic condensin.,Burmann F, Shin HC, Basquin J, Soh YM, Gimenez-Oya V, Kim YG, Oh BH, Gruber S Nat Struct Mol Biol. 2013 Jan 27;20(3):371-9. doi: 10.1038/nsmb.2488. Epub 2013, Jan 27. PMID:23353789<ref>PMID:23353789</ref>
-
[[3zgx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGX OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<references group="xtra"/><references/>
+
</div>
 +
<div class="pdbe-citations 3zgx" style="background-color:#fffaf0;"></div>
 +
 
 +
==See Also==
 +
*[[Condensin|Condensin]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
-
[[Category: Basquin, J.]]
+
[[Category: Large Structures]]
-
[[Category: Burmann, F.]]
+
[[Category: Basquin J]]
-
[[Category: Gimenez, V.]]
+
[[Category: Burmann F]]
-
[[Category: Gruber, S.]]
+
[[Category: Gimenez V]]
-
[[Category: Kim, Y.]]
+
[[Category: Gruber S]]
-
[[Category: Oh, B.]]
+
[[Category: Kim Y]]
-
[[Category: Shin, H.]]
+
[[Category: Oh B]]
-
[[Category: Soh, Y.]]
+
[[Category: Shin H]]
-
[[Category: Cell cycle]]
+
[[Category: Soh Y]]

Current revision

Crystal structure of the kleisin-N SMC interface in prokaryotic condensin

PDB ID 3zgx

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3zgx"
Personal tools