4i44

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{{STRUCTURE_4i44| PDB=4i44 | SCENE= }}
 
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===Aer2 poly-HAMP domains: V33G HAMP1 inverted signaling mutant===
 
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{{ABSTRACT_PUBMED_23424282}}
 
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==About this Structure==
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==Aer2 poly-HAMP domains: V33G HAMP1 inverted signaling mutant==
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[[4i44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I44 OCA].
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<StructureSection load='4i44' size='340' side='right'caption='[[4i44]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4i44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I44 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.88&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i44 OCA], [https://pdbe.org/4i44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i44 RCSB], [https://www.ebi.ac.uk/pdbsum/4i44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i44 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCPB_PSEAE MCPB_PSEAE] Chemoreceptor that plays a critical role in the virulence and pathogenesis of P.aeruginosa in a variety of hosts (PubMed:31511598). Probably acts through oxygen sensing (PubMed:31511598, PubMed:28167524, PubMed:34383467). Uses a heme-based sensor (PubMed:21255112, PubMed:22622145). Could be involved in chemotaxis (PubMed:12142407, PubMed:14987771). When expressed in E.coli, is able to sense and mediate repellent responses to oxygen, carbon monoxide and nitric oxide (PubMed:21255112).<ref>PMID:12142407</ref> <ref>PMID:14987771</ref> <ref>PMID:21255112</ref> <ref>PMID:22622145</ref> <ref>PMID:28167524</ref> <ref>PMID:31511598</ref> <ref>PMID:34383467</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Airola, M V.]]
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[[Category: Airola MV]]
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[[Category: Crane, B R.]]
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[[Category: Crane BR]]
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[[Category: Sukomon, N.]]
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[[Category: Sukomon N]]
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[[Category: Hamp domain]]
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[[Category: Poly-hamp domain]]
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[[Category: Signal relay]]
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[[Category: Signal transduction]]
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[[Category: Signaling protein]]
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Current revision

Aer2 poly-HAMP domains: V33G HAMP1 inverted signaling mutant

PDB ID 4i44

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