2lv6

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{{STRUCTURE_2lv6| PDB=2lv6 | SCENE= }}
 
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===The complex between Ca-Calmodulin and skeletal muscle myosin light chain kinase from combination of NMR and aqueous and contrast-matched SAXS data===
 
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{{ABSTRACT_PUBMED_22908850}}
 
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==Disease==
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==The complex between Ca-Calmodulin and skeletal muscle myosin light chain kinase from combination of NMR and aqueous and contrast-matched SAXS data==
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[[http://www.uniprot.org/uniprot/MYLK2_HUMAN MYLK2_HUMAN]] Familial isolated hypertrophic cardiomyopathy. Defects in MYLK2 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:[http://omim.org/entry/192600 192600]]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:11733062</ref>
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<StructureSection load='2lv6' size='340' side='right'caption='[[2lv6]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lv6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LV6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Hybrid , Solution NMR , X-ray solution scattering</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lv6 OCA], [https://pdbe.org/2lv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lv6 RCSB], [https://www.ebi.ac.uk/pdbsum/2lv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lv6 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/MYLK2_HUMAN MYLK2_HUMAN]] Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.<ref>PMID:11733062</ref>
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[2lv6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LV6 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Anthis, N J.]]
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[[Category: Large Structures]]
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[[Category: Clore, G M.]]
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[[Category: Anthis NJ]]
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[[Category: Grishaev, A V.]]
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[[Category: Clore GM]]
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[[Category: Metal binding protein-transferase complex]]
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[[Category: Grishaev AV]]
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[[Category: Pb-substituted]]
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[[Category: Protein complex]]
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Current revision

The complex between Ca-Calmodulin and skeletal muscle myosin light chain kinase from combination of NMR and aqueous and contrast-matched SAXS data

PDB ID 2lv6

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