4f0z

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{{STRUCTURE_4f0z| PDB=4f0z | SCENE= }}
 
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===Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African Swine Fever Virus Protein A238L===
 
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{{ABSTRACT_PUBMED_23468591}}
 
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==Function==
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==Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African Swine Fever Virus Protein A238L==
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[[http://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN]] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref><ref>PMID:18838687</ref> [[http://www.uniprot.org/uniprot/VF238_ASFM2 VF238_ASFM2]] Inhibits activation of the NF-kappa-B transcription factor by preventing binding of NF-kappa-B subunits RELA and NFKB3 to DNA. Inhibits also the activity of the calcium/calmodulin-regulated phosphatase calcineurin (By similarity). [[http://www.uniprot.org/uniprot/CANB1_HUMAN CANB1_HUMAN]] Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
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<StructureSection load='4f0z' size='340' side='right'caption='[[4f0z]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4f0z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/African_swine_fever_virus_Malawi_LIL_20/1 African swine fever virus Malawi LIL 20/1] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F0Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f0z OCA], [https://pdbe.org/4f0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f0z RCSB], [https://www.ebi.ac.uk/pdbsum/4f0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f0z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref> <ref>PMID:18838687</ref>
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==About this Structure==
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==See Also==
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[[4f0z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/African_swine_fever_virus_malawi_lil_20/1 African swine fever virus malawi lil 20/1] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F0Z OCA].
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*[[Calcineurin 3D structures|Calcineurin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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[[Category: African swine fever virus malawi lil 20/1]]
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</StructureSection>
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[[Category: African swine fever virus Malawi LIL 20/1]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Large Structures]]
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[[Category: Grigoriu, S.]]
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[[Category: Grigoriu S]]
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[[Category: Page, R.]]
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[[Category: Page R]]
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[[Category: Peti, W.]]
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[[Category: Peti W]]
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[[Category: Calcineurin inhibition]]
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[[Category: Calcium signaling]]
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[[Category: Calmodulin]]
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[[Category: Ef-hand]]
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[[Category: Heart]]
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[[Category: Hydrolase-protein binding complex]]
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[[Category: Ion channel]]
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[[Category: Lxvp]]
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[[Category: Nfat]]
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[[Category: Nucleus]]
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[[Category: Phosphatase]]
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[[Category: Pxixit]]
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[[Category: Rcan]]
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[[Category: Skeletal muscle]]
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[[Category: T-cell activation]]
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[[Category: Transcription regulation]]
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Current revision

Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African Swine Fever Virus Protein A238L

PDB ID 4f0z

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