4gai

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{{STRUCTURE_4gai| PDB=4gai | SCENE= }}
 
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===Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra===
 
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{{ABSTRACT_PUBMED_23431173}}
 
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==About this Structure==
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==Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra==
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[[4gai]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAI OCA].
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<StructureSection load='4gai' size='340' side='right'caption='[[4gai]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gai]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GAI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gai OCA], [https://pdbe.org/4gai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gai RCSB], [https://www.ebi.ac.uk/pdbsum/4gai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gai ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Barnes, T M.]]
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[[Category: Large Structures]]
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[[Category: Furfine, E S.]]
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[[Category: Barnes TM]]
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[[Category: Garcia, K C.]]
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[[Category: Furfine ES]]
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[[Category: Hou, J.]]
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[[Category: Garcia KC]]
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[[Category: Kiner, O.]]
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[[Category: Hou J]]
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[[Category: King, B.]]
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[[Category: Kiner O]]
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[[Category: Kovalchin, J T.]]
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[[Category: King B]]
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[[Category: Masci, A.]]
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[[Category: Kovalchin JT]]
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[[Category: Shu, Y.]]
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[[Category: Masci A]]
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[[Category: Thomas, C.]]
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[[Category: Shu Y]]
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[[Category: Townson, S A.]]
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[[Category: Thomas C]]
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[[Category: Beta-trefoil]]
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[[Category: Townson SA]]
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[[Category: Il-1 signaling]]
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[[Category: Il-1beta]]
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[[Category: Il-1r1]]
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[[Category: Il-1ra]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra

PDB ID 4gai

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