4jif
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Co-crystal structure of ICAP1 PTB domain in complex with a KRIT1 peptide== | |
| + | <StructureSection load='4jif' size='340' side='right'caption='[[4jif]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4jif]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JIF FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.701Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jif OCA], [https://pdbe.org/4jif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jif RCSB], [https://www.ebi.ac.uk/pdbsum/4jif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jif ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ITBP1_HUMAN ITBP1_HUMAN] Regulates integrin signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. May play a role in the recruitment of ITGB1 to focal contacts during integrin-dependent cell adhesion.[REFERENCE:8] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Integrin cytoplasmic domain-associated protein-1 (ICAP1) is a suppressor of integrin activation and directly binds to the cytoplasmic tail of beta1 integrins; its binding suppresses integrin activation by competition with talin. Krev/Rap1 interaction trapped-1 (KRIT1) releases ICAP1 suppression of integrin activation by sequestering ICAP1 away from integrin cytoplasmic tails. Here, the cocrystal structure of the PTB domain of ICAP1 in complex with a 29-amino-acid fragment (residues 170-198) of KRIT1 is presented to 1.7 A resolution [the resolution at which I/sigma(I) = 2.9 was 1.83 A]. In previous studies, the structure of ICAP1 with integrin beta1 was determined to 3.0 A resolution and that of ICAP1 with the N-terminal portion of KRIT1 (residues 1-198) was determined to 2.54 A resolution; therefore, this study provides the highest resolution structure yet of ICAP1 and allows further detailed analysis of the interaction of ICAP1 with its minimal binding region in KRIT1. | ||
| - | + | Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide.,Liu W, Boggon TJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 May;69(Pt 5):494-8. doi:, 10.1107/S1744309113010762. Epub 2013 Apr 27. PMID:23695561<ref>PMID:23695561</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4jif" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Boggon TJ]] | ||
| + | [[Category: Liu W]] | ||
Current revision
Co-crystal structure of ICAP1 PTB domain in complex with a KRIT1 peptide
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