4jnm
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties== | |
| + | <StructureSection load='4jnm' size='340' side='right'caption='[[4jnm]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4jnm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JNM FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1LJ:1-[(6-AMINOPYRIDIN-3-YL)METHYL]-3-[4-(PHENYLSULFONYL)PHENYL]UREA'>1LJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jnm OCA], [https://pdbe.org/4jnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jnm RCSB], [https://www.ebi.ac.uk/pdbsum/4jnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jnm ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bair KW]] | ||
| + | [[Category: Bauer P]] | ||
| + | [[Category: Baumeister T]] | ||
| + | [[Category: Buckmelter AJ]] | ||
| + | [[Category: Caligiuri M]] | ||
| + | [[Category: Clodfelter KH]] | ||
| + | [[Category: Dragovich PS]] | ||
| + | [[Category: Fu B]] | ||
| + | [[Category: Gunzner-Toste J]] | ||
| + | [[Category: Han B]] | ||
| + | [[Category: Ho Y]] | ||
| + | [[Category: Kley N]] | ||
| + | [[Category: Liederer B]] | ||
| + | [[Category: Lin J]] | ||
| + | [[Category: Mukadam S]] | ||
| + | [[Category: O'Brien T]] | ||
| + | [[Category: Oh A]] | ||
| + | [[Category: Reynolds DJ]] | ||
| + | [[Category: Sharma G]] | ||
| + | [[Category: Skelton N]] | ||
| + | [[Category: Smith CC]] | ||
| + | [[Category: Wang W]] | ||
| + | [[Category: Wang Z]] | ||
| + | [[Category: Xiao Y]] | ||
| + | [[Category: Yuen P]] | ||
| + | [[Category: Zak M]] | ||
| + | [[Category: Zhang L]] | ||
| + | [[Category: Zhao G]] | ||
| + | [[Category: Zheng X]] | ||
Current revision
Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties
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Categories: Homo sapiens | Large Structures | Bair KW | Bauer P | Baumeister T | Buckmelter AJ | Caligiuri M | Clodfelter KH | Dragovich PS | Fu B | Gunzner-Toste J | Han B | Ho Y | Kley N | Liederer B | Lin J | Mukadam S | O'Brien T | Oh A | Reynolds DJ | Sharma G | Skelton N | Smith CC | Wang W | Wang Z | Xiao Y | Yuen P | Zak M | Zhang L | Zhao G | Zheng X
