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2dhk

From Proteopedia

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[[Image:2dhk.gif|left|200px]]<br /><applet load="2dhk" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2dhk" />
 
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'''Solution structure of the PH domain of TBC1 domain family member 2 protein from human'''<br />
 
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==About this Structure==
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==Solution structure of the PH domain of TBC1 domain family member 2 protein from human==
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2DHK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHK OCA].
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<StructureSection load='2dhk' size='340' side='right'caption='[[2dhk]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2dhk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DHK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhk OCA], [https://pdbe.org/2dhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dhk RCSB], [https://www.ebi.ac.uk/pdbsum/2dhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dhk ProSAT], [https://www.topsan.org/Proteins/RSGI/2dhk TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TBD2A_HUMAN TBD2A_HUMAN] Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.<ref>PMID:20116244</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dh/2dhk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dhk ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Harada, T.]]
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[[Category: Harada T]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: Li, H.]]
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[[Category: Li H]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Tochio N]]
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[[Category: Tochio, N.]]
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[[Category: Watanabe S]]
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[[Category: Watanabe, S.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: national project on protein structural and functional analyses]]
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[[Category: nppsfa]]
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[[Category: paris-1]]
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[[Category: ph domain]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:58:52 2008''
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Current revision

Solution structure of the PH domain of TBC1 domain family member 2 protein from human

PDB ID 2dhk

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