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4jql
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Synthesis of Benzoquinone-Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid== | |
| + | <StructureSection load='4jql' size='340' side='right'caption='[[4jql]], [[Resolution|resolution]] 1.72Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4jql]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JQL FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VJ6:VALERJESOMYCIN'>VJ6</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jql OCA], [https://pdbe.org/4jql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jql RCSB], [https://www.ebi.ac.uk/pdbsum/4jql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jql ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cameron MD]] | ||
| + | [[Category: Hernandez P]] | ||
| + | [[Category: Iqbal S]] | ||
| + | [[Category: Jeso V]] | ||
| + | [[Category: Lograsso PV]] | ||
| + | [[Category: Micalizio GC]] | ||
| + | [[Category: Park H]] | ||
Current revision
Synthesis of Benzoquinone-Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid
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Categories: Homo sapiens | Large Structures | Cameron MD | Hernandez P | Iqbal S | Jeso V | Lograsso PV | Micalizio GC | Park H
