4jr5
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4jr5 is ON HOLD Authors: Zheng, X., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J....) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors== | |
| + | <StructureSection load='4jr5' size='340' side='right'caption='[[4jr5]], [[Resolution|resolution]] 1.91Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4jr5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JR5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.906Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1LS:1-[4-(PIPERIDIN-1-YLSULFONYL)PHENYL]-3-(PYRIDIN-3-YLMETHYL)THIOUREA'>1LS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jr5 OCA], [https://pdbe.org/4jr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jr5 RCSB], [https://www.ebi.ac.uk/pdbsum/4jr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jr5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bair KW]] | ||
| + | [[Category: Bauer P]] | ||
| + | [[Category: Baumeister T]] | ||
| + | [[Category: Buckmelter AJ]] | ||
| + | [[Category: Caligiuri M]] | ||
| + | [[Category: Clodfelter KH]] | ||
| + | [[Category: Dragovich PS]] | ||
| + | [[Category: Gunzner-Toste J]] | ||
| + | [[Category: Han B]] | ||
| + | [[Category: Ho Y]] | ||
| + | [[Category: Kley N]] | ||
| + | [[Category: Lin J]] | ||
| + | [[Category: Oh A]] | ||
| + | [[Category: Reynolds DJ]] | ||
| + | [[Category: Sharma G]] | ||
| + | [[Category: Smith CC]] | ||
| + | [[Category: Wang W]] | ||
| + | [[Category: Wang Z]] | ||
| + | [[Category: Yuen P]] | ||
| + | [[Category: Zak M]] | ||
| + | [[Category: Zhao G]] | ||
| + | [[Category: Zheng X]] | ||
Current revision
Structure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
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Categories: Homo sapiens | Large Structures | Bair KW | Bauer P | Baumeister T | Buckmelter AJ | Caligiuri M | Clodfelter KH | Dragovich PS | Gunzner-Toste J | Han B | Ho Y | Kley N | Lin J | Oh A | Reynolds DJ | Sharma G | Smith CC | Wang W | Wang Z | Yuen P | Zak M | Zhao G | Zheng X
