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4hka
From Proteopedia
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| - | {{STRUCTURE_4hka| PDB=4hka | SCENE= }} | ||
| - | ===Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase in complex with HEME=== | ||
| - | {{ABSTRACT_PUBMED_23333332}} | ||
| - | == | + | ==Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase in complex with HEME== |
| - | [[http://www.uniprot.org/uniprot/T23O_DROME T23O_DROME | + | <StructureSection load='4hka' size='340' side='right'caption='[[4hka]], [[Resolution|resolution]] 2.70Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4hka]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HKA FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hka OCA], [https://pdbe.org/4hka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hka RCSB], [https://www.ebi.ac.uk/pdbsum/4hka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hka ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/T23O_DROME T23O_DROME] Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring (By similarity). Required during larval growth to control the level of potentially harmful free tryptophan in the hemolymph. In the adult the same reaction is the first step in the ommochrome biosynthetic pathway.<ref>PMID:2108317</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Dioxygenase 3D structures|Dioxygenase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Ding | + | [[Category: Ding J]] |
| - | [[Category: Huang | + | [[Category: Huang W]] |
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Current revision
Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase in complex with HEME
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