4he7

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{{STRUCTURE_4he7| PDB=4he7 | SCENE= }}
 
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===Crystal Structure of Brazzein===
 
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==Function==
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==Crystal Structure of Brazzein==
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[[http://www.uniprot.org/uniprot/DEF_PENBA DEF_PENBA]] Taste-modifying protein; sweet-tasting. It is 2000 sweeter than sucrose on a molar basis.<ref>PMID:15118082</ref> Has a pH-specific antimicrobial activity against bacteria (B.subtilis, E.coli and S.aureus) and the fungus C.albicans.<ref>PMID:15118082</ref>
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<StructureSection load='4he7' size='340' side='right'caption='[[4he7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4he7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pentadiplandra_brazzeana Pentadiplandra brazzeana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HE7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4he7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4he7 OCA], [https://pdbe.org/4he7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4he7 RCSB], [https://www.ebi.ac.uk/pdbsum/4he7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4he7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DEF_PENBA DEF_PENBA] Taste-modifying protein; sweet-tasting. It is 2000 sweeter than sucrose on a molar basis.<ref>PMID:15118082</ref> Has a pH-specific antimicrobial activity against bacteria (B.subtilis, E.coli and S.aureus) and the fungus C.albicans.<ref>PMID:15118082</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Brazzein is the smallest sweet-tasting protein and was isolated from the wild African plant Pentadiplandra brazzeana. The brazzein molecule consists of 54 amino-acid residues and four disulfide bonds. Here, the first crystal structure of brazzein is reported at 1.8 A resolution and is compared with previously reported solution structures. Despite the overall structural similarity, there are several remarkable differences between the crystal and solution structures both in their backbone folds and side-chain conformations. Firstly, there is an additional alpha-helix in the crystal structure. Secondly, the atomic r.m.s.d.s between the corresponding C(alpha)-atom pairs are as large as 2.0-2.2 A between the crystal and solution structures. Thirdly, the crystal structure exhibits a molecular shape that is similar but not identical to the solution structures. The crystal structure of brazzein reported here will provide additional information and further insights into the intermolecular interaction of brazzein with the sweet-taste receptor.
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==About this Structure==
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The structure of brazzein, a sweet-tasting protein from the wild African plant Pentadiplandra brazzeana.,Nagata K, Hongo N, Kameda Y, Yamamura A, Sasaki H, Lee WC, Ishikawa K, Suzuki E, Tanokura M Acta Crystallogr D Biol Crystallogr. 2013 Apr;69(Pt 4):642-7. doi:, 10.1107/S0907444913001005. Epub 2013 Mar 14. PMID:23519673<ref>PMID:23519673</ref>
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[[4he7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pentadiplandra_brazzeana Pentadiplandra brazzeana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HE7 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<references group="xtra"/><references/>
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</div>
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<div class="pdbe-citations 4he7" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pentadiplandra brazzeana]]
[[Category: Pentadiplandra brazzeana]]
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[[Category: Hongo, N.]]
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[[Category: Hongo N]]
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[[Category: Ishikawa, K.]]
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[[Category: Ishikawa K]]
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[[Category: Kameda, Y.]]
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[[Category: Kameda Y]]
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[[Category: Lee, W C.]]
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[[Category: Lee WC]]
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[[Category: Nagata, K.]]
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[[Category: Nagata K]]
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[[Category: Sasaki, H.]]
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[[Category: Sasaki H]]
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[[Category: Suzuki, E.]]
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[[Category: Suzuki E]]
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[[Category: Tanokura, M.]]
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[[Category: Tanokura M]]
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[[Category: Yamamura, A.]]
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[[Category: Yamamura A]]
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[[Category: Plant protein]]
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[[Category: Sweet-tasting protein]]
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Current revision

Crystal Structure of Brazzein

PDB ID 4he7

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